diacetyldeath
Bluelighter
- Joined
- Apr 30, 2005
- Messages
- 329
haribo1 said:Many years ago I visited and was offered some. I snorted four 5mg tablets and felt groovy (I have no tolerence). It's a slippery slope, though. I'm interested in more euphoric partial agonists (somewhat like buprenorphine) to prevent tolerence kicking in. In a survey of british prisons, it was found that buprenorphine abuse was rife but people didn't keep upping their dose. In fact, even total drug-monsters said that the same dose kept giving them the same high which is interesting. Alter that side-chain and you could end up with something more euphoric but not tolerence-building...
The holy grail would be a selective, full mu1 agonist (no activity at mu2), antagonist at delta (like buprenorphine), full gamma agonist. I am both curious and very scared to see what will happen to the opiophobic/"narcotics are evil" propogandized community when selective-mu agonists can be created. Since both respiratory depression and tolerance are functions of mu2 and delta, this would be an opioid with a virtually unlimited dose ceiling, no potential for (fatal) overdose, and limited/no physical addiction.
It is possible to prevent the onset of tolerance for the most part already. Do some research on CCK antagonists (Proglumide et al), NMDA antagonists' effects on opioid potentiation and attenuation/prevention of tolerance, and ultra low-dose antagonist (e.g. naloxone) effects on opioid potentiation and attenuation/prevention of tolerance. I have used the CCK antagonist and ULD Naloxone routes to successfully block/somewhat successfully attenuate tolerance (to a point) in the past, and had I known their capabilities, would have killed to have these substances around at the beginning of my opioid "experiences."
Anyway, with enough knowledge and proper application of the above strategies in combination with not going too crazy on dose escalation (it sounds like you are already adequately paranoid/prepared on that subject), it would be substantially easier to maintain a full agonist "habit" with little to no dose escalation in the long-term.
Just some interesting subjects to read about if you haven't already.
-DD