It definitely should work, and should have the same good bioavailability. You'll have to make sure that you clean your ass out first though, since such a tiny amount (µgs) of compound will get totally lost in any shit you have up there. As opposed to, of course, a soution of lower potency compounds. I don't know how, your going to get it up there though, you'll probably have to grease your finger and shove it in old school. I'd rather dilute the blotter in distilled water and use a syringe. That way you get increased surface area for absorption, and an easier method of administration. Best of both worlds! :D