GREAT THREAD
ill throw a few i know all too well out there... that most dont know
METHADONE -
Cats Claw. 25%+ incease in duration using cats claw.
OPIUM and various others opiods - Propoxyphene. Ya, darvocet, its shit alone. HUGE potentiator of opium... stumbled on it years ago w/ huge supply of what i thought was useles darvies. check out its unique p450 properties along with many other pubmed discoveries.... be careful tho.... dangerous and ez drug to OD on. im talking like 1 or 2 darvies with a seriously reduced dose.
OPIUM - Cimetedine. seems to fuck with and kill other opoids (stops vicodin from metabolizing into hydromorph, etc) but it adds one hell of a kick to opium and increases duration.
ummm... magnesium is a must. always have high levels of magnesium obviously... take it with any opiate/oid. helps with absorbtion also.
SOooooooooOoOOOOOoo many prescription drugs will potientiate opiates.... mostly due to unique and strong p450 enzyme inhibition but its tricky stuff and specific to the opiate/oid your fucking around with. Then there are some that potentiate it simply due to synergy of pleasurable effects (or more generally unknown "magic" in da brain
Phenergan even tho it should only potentiate because of its antihistimine properties goes beyond that. many will back me up. there is something more to antihistamines, ESPECIALLY w phenergan, than the sedation effect adding to the nod.
there are a ton of potentiators.... ill post more later. so many unknown ones too... alot of herbal shit people dont know about ta boot
if you want a REAL Ultimate Opiate Potentiation thread then somebody (ill do it eventually
needs to post a nice bigass conclusive list of p450 enzyme inhibitors and inducers and a list of opiates/opoids and how they metabolize/how they can be modified for potentiation. its all out there on the net but nobody has ever gotten more than 50% of the real data on one page, etc etc.