@Sturnam
This link tells the story of someone who used Methylone routinely for a few years (take note, this is
not a link about MDAI per se, just one of the other RC entactogens with similar effects but using different receptor affinities).
Here's what he has to say about repeated usage:
One of the magics about this drug is that you can take it 3 days in a row, without upping your dose.
That is indeed a dangerous feed. That means that I could actually party Thursday, Friday, Saturday without feeling too bombed in school on Monday. And in the start I could even make homework Sunday. But as time went on, and I took it more and more, at some point I began to have the feeling of nothingness afterwards. Feeling of NOT wanting to do ANYTHING other than watch movies and sleep. This feeling would most often leave after a day or 2.
Another magic is that you can keep re-dosing for hours.
I could always re-dose in the start, actually I could always re-dose until lately, for 2 whole years of hardcore use I could re-dose as much and almost as long as I wanted to (bout 12 hours straight) and almost keep the same effect all the way trough.
There’s almost no tolerance build.
For 2 whole years I took it almost every weekend, often more than one day, and the dose only raised from 150mg to 250mg and I felt almost the same euphoria every time.
But a few weeks ago, the tolerance finally hit me! I took the same amount as I always did, and nothing happened, after about 40min. I took the same dose again and almost nothing happened. I thought that this was just a onetime thing, and so I tried the week after, exactly the same happened, and the next week after again, I had at last felt the tolerance. Now I have to take about 500mg to really gain effect, and that’s not something I want, so I have stopped, but that’s a lot harder than I thought it would be, now I even want it in the working days, before I could wait for the weekend. I miss it.
My experience with MDAI is that it is indeed weaker than Methylone. But calling the two simply dissimilar would perhaps be more truthful. More than anything, it is an effective antidepressant (with a little erotic aspect to it) that doesn't interfere with cognition.
I've been treating it as a "work hard, play hard" aid and have been splitting my weeks into two halves:
3-4 days in a row: Follow a Nootropic regimen (Alpha-GPC, Fish Oil, "Chocamine", Piracetam, Oxiracetam, Bacopa Monnieri, Huperzine A, L-Deprenyl, and sometimes Rhodiola Rosea), and study harder than ever before in my life. I saved up enough money to keep my rent and bills at bay for a couple months, that I may have the time I need to finish coding an approximative Physics/Chemistry/AI hybrid engine project of mine, built for modern GPGPU massively parallel processors. During these days, I mercilessly push my creativity and concentration to their limits.
3-4 days in a row: Take ~60mg MDAI as a base early in the day. Read a good book, go out and have a good time, watch a favorite show, whatever it takes to enjoy life to its fullest. I find the experience of threshold level MDAI can feel so subtle and non-drug-like, that if you're truly enjoying your hobbies and general life around you, those empathic feelings of peacefulness and tolerance in all things last pretty much the entire day.
All the while I eat healthy including whey protein, antioxidants, normal levels of multivitamins (not those silly 1000% RDA messes), and sleep fitfully.
Between these two extremes, I've never felt more balanced and capable. Before taking this measure, I had been getting frustrated over the little things in life, and my programming project was therefore running into obstacle after obstacle. Uncertainty and despair at my personal limits had begun taking its toll. I was frequented by thoughts of self-doubt, a decline in motivation and general lack of focus.
After nearly 4 weeks now of this, I've worked my way around every tight spot I had coded myself into with the Physics chunk of the engine, and haven't heard a peep out of those old, obnoxious negative thought-loops we all sometimes fall into.
The only trouble I've had from this regimen is that I end up sleeping 10 hours a day, as by the end of each day from either half of the week I'm completely...
completely exhausted. But in a satisfied, self-assured sort of way. And every morning I wake up full of energy, eager and grateful to just be alive.
The time I spend away from MDAI I do not desire taking it in the least.
I think I'll try a month without any MDAI at all now, to see what comes of it. As has been suggested before, a low-low dose of L-Deprenyl (2.5 mg once or twice a week) seems to keep away post-entactogen depression, as I've never experienced any unpleasant after effects.
Then again, I'm usually too busy with work to care by that swing of the pendulum, so perhaps that has more to do with it than anything.
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If there is any substance I would like to see studied and recognized as a Nootropic or obtain legitimate antidepressant prescribability status, it would have to be MDAI.