Dangerous interactions between these drugs?

Hello, bluelight.

I have acquired a bunch of drugs that will be taking with good friends before, at and after a party. I'm only concerned that there might be some acute dangers that I'm not knowledgeable enough to spot. Here's a list of drugs I'm planning on taking during the course of one night:

• Caffeine (throughout)
• Mirtazapine, 60 mg (another 30 mg later on)
• Alcohol (until GHB)
• Salvia
• MDPV
• Viagra
• Xanax, 2 mg (another 1 mg after 2C-B)
• GHB
• Ketamine, low dose
• 2C-B, 30 mg
• DMT
• Tramadol 400 mg
• Weed
• Opium

Probably in that order.

There's a party. At first, at around 5 PM, I will be taking mirtazapine for my apathy/depression that emerged as depersonalization from JWH-018 faded. It makes me feel normal, happy and sociable. It's very necessary. (Not prescribed.) Small amounts of alcohol will be had until Xanax is taken. Salvia will be tried for the first time, and I can't imagine that this will be a problem. MDPV will also be tried for the first time after salvia. The dosage will be small and carefully measured. During MDPV, which will probably last until around 9 PM, Viagra might be needed. To ease the comedown, if I experience one, I will take 2 mg Xanax (my first time taking any benzo, although mirtazapine supposedly is similar in high doses). After this, GHB will be tried for the first time. Carefully, of course. A low dose of ketamine (one that supposedly won't sedate me heavily - also first time) will be had after the GHB. Afterward, I will take 30 mg of 2C-B, which will probably last until the morning. According to my friend, 2C-B resembles 25C-NBOMe, so I have some idea of what to expect. This is the scariest part when it comes to drug interactions, in my opinion. I will smoke DMT when coming off of 2C-B. After this, I will take 400 mg of tramadol, if my second dose of 30 mg mirtazapine has almost worn off. I very much enjoy tramadol, and I imagine 2C-B will leave me pretty stimulated. Sleep deprivation and stimulation doesn't feel too good. To potentiate the tramadol, I will smoke weed, and after smoking a little bit of opium, I will go to sleep. Whenever I feel tired (obviously before the MDPV), I will drink copious amounts of coffee. Cigarettes might be smoked at times as well.

I've looked around on the internet to find possibly dangerous drug interactions. My main concern at first was that mirtazapine together with tramadol might cause serotonin syndrome, but according to other people's experiences, I'll be safe. If there's a risk, I'm willing to take it, and I'm informed about it. I might skip the second dose of mirtazapine to be sure. I delayed asking for an SSRI prescription so I would be more flexible with the serotonergic compounds, as mirtazapine isn't that long lasting in my experience.
Now, moving on. I'm assuming the psychedelic effects of thujone in absinthe are a myth, and that I will really just be intoxicated by ethanol. But I will likely have had enough for the effects to linger when I'm smoking salvia. This shouldn't be a problem according to trip reports, so I guess I'm just wasting space and time here. But then I will be affected by mirtazapine, alcohol and MDPV at the same time. Especially the mirtazapine and MDPV sound slightly scary. Would a noradrenergic and specific serotonergic antidepressant (NaSSA) and a norepinephrine-dopamine reuptake inhibitor (NDRI) have potentially dangerous interactions? I am pretty sure mirtazapine gives me normal serotonin levels (it makes me feel like before my JWH-018-induced depersonalization and apathy).

I will let the GHB fade completely before taking ketamine, and I'll let the ketamine fade completely before taking 2C-B, so unless some non-psychoactive effects accumulate and cause organ failure or something, I should be fine, don't you think? Now, is it stupid to take an SNRI (tramadol) with lingering effects of 2C-B, a serotonergic psychedelic?

If you took the time to read my entire post, thank you. It could probably be shorter. In summary, the above is a list of drugs I'm planning to take, and below it is a description of how I'm planning on taking them. I'm thinking there won't be any dangerous interactions here, but just to be sure, I ask you guys, hoping someone particularly knowledgeable will read this.

Also, I was concerned with excitotoxicity from ketamine. Could it be prevented/lessened if taken with Xanax?

Tyvm,
Cosmopolis :D:D:D:D

--> OD

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Way too much sedation in my opinion...skip the MDPV and salvia altogether and replace the MDPV with just about any other upper, but definitely no salvia...

GHB, Mitrazapine, Xanax, ketamine and opium...not sure of the timeline here, but that's going a little overboard...I'd skip the mirtrazapine altogether and save the Xanax for the very end if you're not too sedated from the opium...If you're actually serious about this, it's extremely unpredictable....no reason to even do half the drugs on the list....although some are short acting enough that it might not matter...I'd pare it down a bit myself.

Edit:mixing drugs in the way you're suggesting is very reckless, I suspect you know this, part of me thinks you may be trolling just to see how people respond, but I don't really know...

Mixing drugs is like cooking, or pairing food with wine....You want everything to compliment each other from start to finish...You don't want anything to clash or overpower anything else too much....You may want to just take the 2-cb with one mg of Xanax in the beginning, maybe little ketamine thrown in later...and much later, maybe either a little G, more Xanax, or opium....Of course, you could maybe do a little more of each, or do a different combo, but what you're proposing is an absolute mess...

You are trying far, far too many potent psychotropic agents in one sitting - if you haven't even tried them first, you are actively looking for trouble.

I'm only concerned that there might be some acute dangers that I'm not knowledgeable enough to spot.

Click to expand...

1. Mirtazepine, although it may make you feel better, will interact negatively (stop them from working) with drugs affecting serotonin receptors (namely 2C-B), because mirtaz works by binding to those receptors and stopping them from being activated. It will also reduce the effects of stimulant drugs by competitively blocking norepinephrine/adrenaline receptors. And regardless: you are trying to feel good through other chemical means - it is not necessary, and if you deem it is necessary for your mental health then you shouldn't be taking 14 drugs

2. Alcohol and Xanax is easy to over-do, and is lethal in overdose. Xanax is generally a pretty good dis-inhibitor, like alcohol, so though you may feel confident you won't take any more than one dose, it may not actually happen that way. This combo increases your risk of reckless, impulsive behavior. There is also a good chance you'll black out if you don't regularly combine benzos and know your limit already. Alcohol and Xanax generally reduce the efficacy of psychedelics and can potentate depressants like tramadol and opium to uncomfortable or deadly levels.

3. Salvia is not something to be done in a party. You say you 'can't imagine it being a problem", but smoking salvia is about as directly enjoyable as having someone hit you over the head with a shovel - especially the first time, before you even know what the fuck is going on.

4. MDPV and Viagra increases the risk of strange alterations in blood pressure, stroke, overexertion, cardiac arrest. Unless you only have 1 dose of MDPV in your posession and literally cannot find any more, you'll probably end up doing it all and being tweaked. PV is very compulsive, and combined with Xanax/alcohol that's a recipe for disaster.

5. You don't know what GHB dose is good for you - go too low and it's just mild relaxation, but if you overshoot you will either get ghastly sick, or end up blacked out, in unrousable, coma-like sleep on the floor, for a few hours... In combination with benzos or residual alcohol you could stop breathing. You could also choke on your own vomit.

6. 2C-B while you are sleep deprived is a bad idea. 30mg is a rather high dose for someone who has never tried it. And the 25X compounds are subjectively very different from the 2C-X series - you can't generalize based upon one friend's data point. Also, oral 2C-B takes a good 2 hours or so to come up...

7. Ketamine could cause serious depersonalization/derealization, resulting in anxiety, resulting in more derealization - an endless spiral.

8. Smoking DMT while coming off your 2C-B, is pretty safe compared to everything else you're combining, but if you go for a breakthrough dose, it's going to be very taxing on your mind and body. Especially your mind. You risk a panic attack, or outright collapse.

9. Cigarettes and coffee will eventually make you get physically sick. Too much will give you diarrhea. Mixing caffeine and stimulants potentiates them both. Combining them with psychedelics and stimulants greatly increases the uncomfortable feelings you get (jitters, nausea etc), and both increase blood pressure pretty seriously = increased risk of stroke.

8. Tramadol is also a SNRI drug, and 400mg is a serious dose for a sleep deprived individual. Unless you are a regular opioid user, that dose will probably make you stay up all night vomiting, if you don't have to call an ambulance first for a possible seizure, or collapse from exhaustion before then.

9. Combining tramadol with opium is like adding a .22 calibre pistol onto a naval battleship. Just stick with the opium, otherwise you have another opportunity for drugs to interact.

Look, dude, I'll be honest. If you carry through with this you will end up in a hospital.

There are several drugs you mentioned that you are not to be taken lightly.
Salvia is every bit as mentally scary and disorienting as a JWH overdose.
MDPV has driven people to insanity because it loses "fun" very quickly, and due to its very nature at reward sites in the brain, it compels you to take more and more and more. Even though you're not feeling anything but tweaked.
Mixing benzodiazepines and alcohol at a party has been the cause of too many ruined parties and cop calls.

You will also make an ass of yourself at the party, first by being "that kid with all the drugs", then by getting too fucked up to socialize. You don't know your limits for half these drugs.

You are not ready for the mental implications this trip is going to incur, even if your body could handle it. If you think your depersonalisation is bad now, you should wait until you've had your ass kicked through the six fractal planes and back again several times in the span of an hour. And yes, some of these combinations are (knock wood) very safe, but not all at once.

seiko, brilliant post.

The the OP: Look, I've been there, I went to a music festival, and decided to take 8 different drugs at once with my best mate. Seemed like a brilliant idea, and they were less intense than at least half of the drugs on your list.

It turned out... real bad. Like, we both ended up in hospital kinda bad. My mate lost his mind, and my body threw a hissy fit at me.

It's not worth it. You will regret it. Save the drugs, combo two at most (Opium and Weed would be my personal choice), and enjoy the party -- not the emergency room.

death waiting happen i would say

someone already said X out the salvia, most people find it to have no recreational enjoyment. IDK if you have used it before, but if not I would suggest against it, especailly combined with all those other things.

This can't be serious. Nobody is that stupid to do that many different drugs in one evening.

Sekio said it all. There are far too many dangerous interactions going on. Alone Alcohol, GHB, Xanax and the Opioids combined could kill someone easily. Letting alone things like Mirtazapine and Ketamine.

This thread is one of the most ridiculous I have seen here on BL, and there were lots of really stupid ones...

Sekio actually did a decent job of breaking down specifically what makes this a bad idea....It's really too much to even comprehend or to be believed! Even if you had no regard for your own safety or sanity, this just wouldn't be at all pleasant....so many wild cards....the salvia comment is particularly amusing to me....and I even overlooked a few key things on the first read!

I cant imagine the hangover if you survive this.

Why the hell would you take caffeine? And Viagra doesn't do much for someone with out erectile dysfunction. Literally the only effects you'll get are reduced refraction time, combined with certain things, you can eliminate it... I know this from experience, and studies have shown reduced refraction was the ONLY effect in young male subjects. And taking tramadol with opioim is the equivelant to popping a few Vicodin after a shot of H... And without an opioid. Tolerance, 400mg tramadol alone will have you puking, thinking your dying... If this is serious, your a misguided kid with no notion of what drugs are, or even how to use them recreationally... (edit:and again on the tramadol... You won't be getting laid on this kavorkian esque cocktail hehe)

Thanks for the replies, guys. Here's some clarification and more details.

I was not planning on getting drunk, not even particularly tipsy. Three beers does little for me, but it does make me more sociable. The salvia was going to be smoked before the actual party, with good friends only. I would definitely not make an ass of myself, because I would not be the only person there to be doing multiple drugs. To those concerned about the tramadol and opium, I've done tramadol many times and I've found 400 mg plus a couple of beers is my optimal dose. I've never had a seizure from it. If I took mirtazapine, I suppose it could happen, so I have decided to drop the antidepressives. Opium would be smoked in moderation after tramadol, and I feel safe doing this. I most likely will have fallen asleep by then. In that case, the opium will be smoked the next morning and there won't be a problem. I've been dependent on high doses of fentanyl and tramadol. I feel very safe doing opioids and I know my limits.

The timeline describes that most of the downers will be taken after most of the other drugs have all worn off almost completely. @Lorne?, I don't expect getting laid at 5 AM in the morning, lol. I've taken Viagra before, and to me, it cures whiskey dick perfectly fine. If it's not needed at the moment, I won't take it, of course. I have low blood pressure, but a good heart, so I don't expect viagra + MDPV will give me a heart attack. I have a naturally high tolerance for most things, including opioids/opiates and stimulants. I definitely won't puke from the tramadol alone.

About the Xanax, I'm reconsidering taking it early. If the MDPV comedown becomes very uncomfortable, I will take 0.5 mg and see how it affects me. This is how I'm planning on taking the GHB as well. I will dilute it well and if I'm not satisfied with the effects, I will carefully increase the dosage. I will have several days before this party to test out some of the drugs as well to find my dosage, including GHB and MDPV.

Remember that many of these drugs are short acting and will not interfere psychoactively with most other drugs on the list. Some organ failure seems to be the biggest risk, or too much stress on serotonin receptors due to mirtazapine (which I decided not to take), MDPV and 2C-B.

To everyone who thinks I'm trolling or misguided, I'm certainly not. I've researched the drugs I'm planning on taking pretty thoroughly. Of course, when mixing this many drugs, it's hard to tell the outcome. It's not about being stupid or misguided, I guess I simply have a different outlook on life than most of you do.

Thanks again for the replies, though. I'll think more about this. The immediate dangers pointed out mostly revolve around combining downers, though. I'm aware that Xanax, alcohol, opium and tramadol are a dangerous combination, but none of them will be taken with any other downer in full effect. I chose Xanax for its short duration, so I can drink a little bit of alcohol beforehand. But yeah, I'll drop the first administrations of Xanax and save it for the end of the 2C-B trip. If I'm still alive/awake (I will probably fall asleep), I'll wait for the Xanax to wear off before taking tramadol, which I've safely combined with opium several times.

Edit: I'll also reduce the 2C-B dosage to 15-18 mg.

even so you are asking for trouble with that sort of menu, i cant see why you would want to even mix some of them unless you have something to prove or are just on some sort of suicide ride.

A "suicide ride" is about it, I guess. I'll report back after/if it happens.

All I can say that this is totally unnecessary.
Frankly the wonderful effects from combining drugs quits working after maybe 3, then it just becomes a clusterfuck and you lose where your minds at.
At shows I may do 6 drugs in a night but even then I feel as it's too much.

I just find it funny you're going to try all these different drugs for the first time at a party. You got your whole life to try these substances. Why not just stick with one or two. GHB and Xanax is such a dangerous combination and I would highly advise that you don't use the two together. With the list you provided you'll probably end up falling asleep.

You're either a troll or very, very misguided. You immediately mention you plan on taking a benzo for the first time and combining it with alcohol... at a party. That's already a dangerous enough interaction, much less all the other drugs you plan on combining.

Sekio did a good job explaining why this is a bad idea. But even the most well thought out and rational prediction of the potential interactions in this drug cocktail is pretty much a waste of time because of the scope of things that can possibly go wrong is well beyond speculation, especially given you are naive to many of the drugs listed.

More is not better when it comes to drugs. You'll be so out of your mind that you won't possibly be able to enjoy yourself. The mere prospect of all the things that can potentially go wrong should be enough of a buzzkill to make you think twice about doing this.

Moredopamine said:

You're either a troll or very, very misguided. You immediately mention you plan on taking a benzo for the first time and combining it with alcohol... at a party. That's already a dangerous enough interaction, much less all the other drugs you plan on combining.

Sekio did a good job explaining why this is a bad idea. But even the most well thought out and rational prediction of the potential interactions in this drug cocktail is pretty much a waste of time because of the scope of things that can possibly go wrong is well beyond speculation, especially given you are naive to many of the drugs listed.

More is not better when it comes to drugs. You'll be so out of your mind that you won't possibly be able to enjoy yourself. The mere prospect of all the things that can potentially go wrong should be enough of a buzzkill to make you think twice about doing this.

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I get a feeling that many of you posted without reading it all. They might be done during the course of one night, but very few of these will actually be active at the same time, at least not significantly active. It's more like an experiment and a test. If I can't handle it, I can't handle it and obviously won't take the next drug on the menu. If I fall asleep, I fall asleep. If I do throw up, fall asleep, get a panic attack or any of the range of possible negative outcomes, I will simply stop. GHB and Xanax are not going to be active at the same time. I'm not afraid of throwing up or having a bad time, I'm just trying to avoid dying. I'm not even going to say I expect to be able to keep going. I expect that I'll fall asleep at some point.

The point of the OP was to make sure I won't get serotonin syndrome or similar. I'm capable of taking drugs in moderation. There will be time to find the optimal dose of Xanax and GHB beforehand.

Some of you are forgetting that alcohol isn't simply equal to being drunk. Being drunk and taking a lot of downers is of course incredibly dangerous. Having 2-3 beers and taking small amounts of downers, however, is not as dangerous. Drinking 3 beers, waiting for its effects to wear off and then taking a single milligram of alprazolam is not particularly dangerous, especially when you're a tall and heavy person with a fast metabolism. Thanks to the advice I got, I'm not going to take the antidepressives, I'm going to lower the 2C-B dosage, I'm going to not take the first dose of Xanax and I'm going to experiment with GHB beforehand. I might also not smoke the salvia. Very useful advice that I appreciate. But there really is a difference between 6 mg Xanax + a six-pack of beer and 2 mg Xanax after 3 beers have nearly worn off.

This is a list excluding caffeine, weed, Viagra and the drugs I decided not to take. Additional list items like caffeine and weed makes the list look scarier. Keep that in mind. I also decided that tramadol might be risky after all that 2C-B serotonin. Drugs that aren't separated by an empty line might be significantly active at the same time.

About three beers
MDPV

MDPV
GHB

Ketamine, low dose

2C-B, 30 mg
DMT
Xanax, 2(?) mg

Weed
Opium

I guess that concludes the thread. Thanks for your concern and advice. The above list isn't too bad, is it?

Do you know a little about half-life of a drug ? Half-life is the time it takes for a substance to lose half of its pharmacological activity.
Alprazolam (Xanax) half-life is : 11.2h not including metabolite
Tramadol : 6h
GHB : 1h
Alcohol depend greatly on how much you drink in case of 3 beer its about 3h
Ketamine : 3h
2C-b : about 6h
THC (weed) : About 50h
Caffeine : 5h
Opium may last for pretty long too
And I dont know for the rest BUT yes a lot of these drugs will be active all at the same time

QUARE said:

Do you know a little about half-life of a drug ? Half-life is the time it takes for a substance to lose half of its pharmacological activity.
Alprazolam (Xanax) half-life is : 11.2h not including metabolite
Tramadol : 6h
GHB : 1h
Alcohol depend greatly on how much you drink in case of 3 beer its about 3h
Ketamine : 3h
2C-b : about 6h
THC (weed) : About 50h
Caffeine : 5h
Opium may last for pretty long too
And I dont know for the rest BUT yes a lot of these drugs will be active all at the same time

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Sounds about right. You're not completely right, though. Notice I said "significantly active". The effects of Xanax don't last long, and it's the depressive effects of Xanax in combination with other depressants that are dangerous, not the presence of the molecule itself. Tramadol and opium will be taken last, so their half-lives are irrelevant. GHB can almost be ignored because of its short duration. Same with ketamine. The early drugs (alcohol, MDPV, GHB and ketamine) are all relatively short lasting (in effects). Alcohol and MDPV can safely be mixed to this degree (slight alcohol intoxication and a low dose of MDPV). When GHB is taken, the alcohol should be so insignificantly active that it shouldn't be a problem. People purposely mix GHB and alcohol carefully, so if I'm careful with the GHB, I should be safe. Now, GHB and ketamine do not mix well according to reports, but this too should not be a problem because the GHB will wear off quickly and neither will be a big dose. 2C-B, DMT and Xanax have been mixed safely many times. Only DMT will be a high dosage. The only worry now is that the Xanax after the 2C-B/DMT will potentate the tramadol and opium, which it inevitably will. Luckily I will probably fall asleep from the Xanax, as it will be very late/early morning and I will be very tired. If coffee is enough to keep me awake, I will wait for the Xanax to fade before taking tramadol and opium. I will leave the party mid 2C-B and be by myself or with only a few close friends. Also, coffee is not potent enough to affect the other drugs dangerously.

If I die, I die. If I become mentally retarded I will try my best to tell you guys that this was a bad idea.