Dangerous interactions between these drugs?

[QUARE]

Also, coffee is not potent enough to affect the other drugs dangerously.

That is not true, in low dose coffe feels pretty weak but because of its pharmacology it may have a HUGE impact mixed with MDPV. Caffeine antagonise Adenosine. Adenosine is a purine that regulate the flow of catecholamine (Dopamine, Norepinephrine, Epinephrine).

People really underestimate Caffeine, in heavy dose it produce severe delirium because catecholamine stop being regulated.

I know by experience that Caffeine mixed with Methylphenidate (Ritalin) cause paranoid delirium, it will probably cause the same with MDPV.

 

[Cosmopolis]

That is not true, in low dose coffe is not feels pretty weak but because of its pharmacology it may have a HUGE impact mixed with MDPV. Caffeine antagonise Adenosine. Adenosine is a purine that regulate the flow of catecholamine (Dopamine, Norepinephrine, Epinephrine).

People really underestimate Caffeine, in heavy dose it produce severe delirium because catecholamine stop being regulated.

I know by experience that Caffeine mixed with Methylphenidate (Ritalin) cause paranoid delirium, it will probably cause the same with MDPV.

Did not know that! I guess I'm skipping the coffee as well. Tyvm!

 

[Lorne?]

I thought you said you we're skipping the Tramadol? And FYI, serotonin syndrome is a bitch! You seem bright, but you can 't possibly comprehend how these drugs can even subtly effect each other. It is different concerning drugs you have exp with, combing multiple things you've never tried is fucking crazy, no matter how much you research. But I've been there(not quite like this) and you at least seem to be thinking it out, planning etc. just cut a few unneeded things from the list, and be very conservative with doses.

 

[RTrain]

So is this like the only night you have to party in the next 3 years?

 

[Cosmopolis]

I thought you said you we're skipping the Tramadol? And FYI, serotonin syndrome is a bitch! You seem bright, but you can 't possibly comprehend how these drugs can even subtly effect each other. It is different concerning drugs you have exp with, combing multiple things you've never tried is fucking crazy, no matter how much you research. But I've been there(not quite like this) and you at least seem to be thinking it out, planning etc. just cut a few unneeded things from the list, and be very conservative with doses.

I kind of forgot that I decided on that. Probably will skip it. Weed and opium will do just fine.

So is this like the only night you have to party in the next 3 years?

I want to see how many new drugs I can take in a day and still be fine. I'm sure it will be enjoyable, guys. If something goes wrong, it probably won't go horribly wrong.

 

[Moredopamine]

I get a feeling that many of you posted without reading it all. They might be done during the course of one night, but very few of these will actually be active at the same time, at least not significantly active. It's more like an experiment and a test. If I can't handle it, I can't handle it and obviously won't take the next drug on the menu. If I fall asleep, I fall asleep. If I do throw up, fall asleep, get a panic attack or any of the range of possible negative outcomes, I will simply stop. GHB and Xanax are not going to be active at the same time. I'm not afraid of throwing up or having a bad time, I'm just trying to avoid dying. I'm not even going to say I expect to be able to keep going. I expect that I'll fall asleep at some point.

The point of the OP was to make sure I won't get serotonin syndrome or similar. I'm capable of taking drugs in moderation. There will be time to find the optimal dose of Xanax and GHB beforehand.

Some of you are forgetting that alcohol isn't simply equal to being drunk. Being drunk and taking a lot of downers is of course incredibly dangerous. Having 2-3 beers and taking small amounts of downers, however, is not as dangerous. Drinking 3 beers, waiting for its effects to wear off and then taking a single milligram of alprazolam is not particularly dangerous, especially when you're a tall and heavy person with a fast metabolism. Thanks to the advice I got, I'm not going to take the antidepressives, I'm going to lower the 2C-B dosage, I'm going to not take the first dose of Xanax and I'm going to experiment with GHB beforehand. I might also not smoke the salvia. Very useful advice that I appreciate. But there really is a difference between 6 mg Xanax + a six-pack of beer and 2 mg Xanax after 3 beers have nearly worn off.

This is a list excluding caffeine, weed, Viagra and the drugs I decided not to take. Additional list items like caffeine and weed makes the list look scarier. Keep that in mind. I also decided that tramadol might be risky after all that 2C-B serotonin. Drugs that aren't separated by an empty line might be significantly active at the same time.

About three beers
MDPV

MDPV
GHB

Ketamine, low dose

2C-B, 30 mg
DMT
Xanax, 2(?) mg

Weed
Opium

I guess that concludes the thread. Thanks for your concern and advice. The above list isn't too bad, is it?

I did read your post. It's just so ridiculous that it isn't worth entertaining a serious reply.

No one on BL can possibly tell you what effect all these drugs are going to have on you. The only thing that is certain is that it's dangerous and stupid. You may as well chug a bucket of paint mixed with a bunch of cleaning chemicals. 8(

 

[RTrain]

Well I just would like to ask what have you used that is similar to the substances like MDPV, GHB and Ketamine? I mean these are drugs that people use to get seriously f'd up. You are saying you haven't even tried these things on their own, correct? Therefore you have no basis for what is a normal dose, you have no basis for too much or not enough. Now you throw in the fact that you are experimenting with new substances while your brain is all haywire and out of wack because of other things you already used.

Honestly this half seems like you are pulling people's legs on here with how ridiculous of an idea this is. So if you are serious just realize it is absurd enough to come across as a ruse.

 

[Cosmopolis]

Well I just would like to ask what have you used that is similar to the substances like MDPV, GHB and Ketamine? I mean these are drugs that people use to get seriously f'd up. You are saying you haven't even tried these things on their own, correct? Therefore you have no basis for what is a normal dose, you have no basis for too much or not enough. Now you throw in the fact that you are experimenting with new substances while your brain is all haywire and out of wack because of other things you already used.

Honestly this half seems like you are pulling people's legs on here with how ridiculous of an idea this is. So if you are serious just realize it is absurd enough to come across as a ruse.

If you read the thread, you'll see that I said at least twice that there will be time to experiment with individual drugs beforehand, and that neither GHB or ketamine will be taken to get "seriously fucked up". It's not black and white, simply "on" it or "off" it. There is a linear level of intoxication and I'm not planning to go far on either.

The effects can be predicted by looking at which receptors the individual drugs work at. It's usually the effect that is dangerous, not the presence of the molecule. If there is only a very slight level of activity left, it can no longer be considered dangerous to mix with drugs that would be dangerous to mix it with when peaking, for example. This entire evening is probably far more predictable than any of you want to imagine. I respect that you believe otherwise, but really, I believe you're exaggerating. What you're imagining is just cramming the peak effects of all the drugs on the first list together into one death-inducing intoxication. But the effects will in actuality be separate. One drug goes in and out. Another one goes in and out. With downers, the danger is DEFINITELY the effect and not the presence of the molecule. Tiny remains of Xanax will not affect the opium dangerously. Are you guys forgetting that most of these drugs have been mixed many times? Especially benzos and opiates. Why are people freaking out about benzos and opiates when they're not even going to be active at the same time? You say there's no telling the outcome of this, which is why it's an "experiment" (I just really don't care if it's risky), but I believe it's pretty predictable.

MDPV and alcohol have been mixed many times. MDPV and GHB have also been mixed. There shouldn't be a problem with this as long as both are taken in moderation. The worst thing that can happen is embarrassment, I think. The GHB will be measured beforehand so it's not affected by poor judgement. The MDPV will wear off eventually, and then there will be time for a long, sober break before ketamine, another break, and then 2C-B, which has been mixed with DMT many times. Xanax to ease the end of 2C-B is also not unheard of. This is when I'll probably fall asleep. If not, opium and weed definitely will not make any residual effects of 2C-B blow up and kill me.

All in all, not that crazy a night. Some of you are clearly overreacting. You sober up pretty fast from a little bit of alcohol, GHB, MDPV and ketamine, and none of them will be very active at the same time. Mixed residual effects will probably not pose a risk here. It might be unpleasant for sure. That won't kill me. That's the first half. Then there's 2C-B and DMT, which is the second half, plus a "finale" with weed and opium. See? It's not one giant, fucked up cocktail of a dozen drugs, it's planned, the drugs are separated by sobriety.

 

[sekio]

The effects can be predicted by looking at which receptors the individual drugs work at.

You can make generalisations, but you can't predict ahead of time how you will respond to a drug you have never taken before. You don't account for allergic reactions, idiosyncratic responses, or the whole set and setting thing. These are all factors that cannot be downplayed. You also can't make predictions about how much two drugs will potentiate each other in a given individual.

It's usually the effect that is dangerous, not the presence of the molecule.

This is meaningless weasel wording. The effects are there because the molecule is present, and if the molecule is present it produces effects. Just because the mind feels sober doesn't mean the body isn't effected. You do not re-establish equilibrium immediately after the drug "wears off", there are indeed residual effects. Your liver doesn't care how high you feel - the enzymes still respond to drugs, and some drugs induce changes that stay until well after they have cleared. (like MAOIs).

Many drugs, or their metabolites, alter the metabolic rate of other compounds. Some potentiate each other exponentially. Some secondary metabolites are still active.

This entire evening is probably far more predictable than any of you want to imagine. I respect that you believe otherwise, but really, I believe you're exaggerating.

Who are you trying to convince with this sort of talk? The best laid plans of mice and men oft go awry, as it were. What if you get hit by a bus? What if plans change? What if the MDPV makes you go all binge-crazy?

Especially benzos and opiates. Why are people freaking out about benzos and opiates when they're not even going to be active at the same time?

Because benzos and opiates results in respiratory depression 9 and a half times out of 10, and because the combination is more lethal than either alone.

MDPV and alcohol have been mixed many times. MDPV and GHB have also been mixed. There shouldn't be a problem with this as long as both are taken in moderation.

MDPV is not a drug that leads to being "taken in moderation". And yeah, PV and all sorts of shit has been mixed; that does not mean it's a good idea. Especially given that PV leads to erratic, paranoid behaviour in a lot of people. Which, again, you cannot predict ahead of time.

The worst thing that can happen is embarrassment, I think.

This kind of thinking will be the end of you. The worst that can happen, of course, is death.

All in all, not that crazy a night.

13 drugs in a night isn't "that crazy"? Do you fuck polar bears at bedtime and play badminton on the Interstate freeways before you've had your morning coffee?

If you knew better than us about the safety of your binge, why did you ask? It sounds to me like you are trying to convince yourself, not us. There are just too many powerful psychotropics you are trying for the first time to say that it is "predictable". Many of them alter your mental and physical equilibrium for quite some time - drugs do not clear out of your system like flipping a switch.

 

[Crankinit]

This thread is ridiculous, getting a real laugh out of it.

 

[QUARE]

You seem determined to do this trip regardless of all warning we gave you. Are you not afraid that if anything go wrong you start panic and tell your self " I should have listen to all those advise what am I going to do now, IS IT TOO LATE" .

 

[crazycatman]

Why bother asking for advice if you're going to do it anyway?

 

[Cosmopolis]

Why bother asking for advice if you're going to do it anyway?

You didn't really think I was asking "Should I just drop the whole thing?" did you? I was asking if there are dangerous interactions. Dangerous interactions like mirtazapine and tramadol, like coffee and MDPV (apparently), like alcohol and GHB. Did you read the thread at all? Did you notice that I decided to skip several drugs after advice? Because I sure did. No, "Don't do any of the drugs" was not the advice I was hoping for. "This is a ridiculous thing to do" is not a dangerous interaction. It's an opinion that is utterly unimportant to me, an opinion that might be true for you, but not for me. I personally would LOVE to take 14 drugs in a night. It's not the first time I take many different drugs in a short amount of time. Stop missing the point of the thread completely. I am not asking if I should do it or not do it, I am asking if there are dangerous interactions on the list. Apparently there are few.

@QUARE, if I start to panic and having a shitty time, it's not the end of the world. Even if I die, it's not the end of the world, but I prefer to avoid dying. However, if your advice is "Don't do any of the drugs on the list because I wouldn't", then yes, I will ignore your good advice and do it anyway. I thought you guys had learned that telling people to not do drugs isn't effective, but giving advice on how to lower risks and harm is. What I'm getting here is several people with a different outlook on life than me telling me that they wouldn't do this many drugs in a night, yet I will, and I am determined to do so. I did not ask if I should or should not do a bunch of drugs, I asked if there are immediate dangers such as serotonin syndrome or heart attack. I am getting little such advice, and instead I'm getting people telling me to just drop it, that it's a ridiculous thing to do. Well, luckily, people are different and that is a subjective opinion. I personally don't find it ridiculous. I have gotten good advice from this thread that I have followed, despite crazycatman's ridiculous question, but now it's just turning into a waste of time. I'm looking forward to taking a whole bunch of drugs and experiencing altered states of mind. I think it will be amazing.

Only a few days left. I'll write you a good trip report.

@sekio
People have potentated opiates with benzos for a long time.

/thread

Edit: Despite what it may seem like, I do appreciate the advice and concern, but "Drop the whole thing because it's unpredictable" wasn't the advice I was looking for. Like I said early on, "it's risky and unpredictable" isn't enough for me to forget about it. I'm just trying to eliminate certain death and whichever syndrome is bound to happen with this combination. "Taking X and Y at the same time will probably result in syndrome Z" would be perfect advice, as opposed to "This is unpredictable, don't do it", which I have of course considered already.

 

[Cosmopolis]

I'm not going to type a trip report. It would be very lengthy, and it wouldn't come close to DMT alone, which was the highlight of my week and probably life. I vomited and I think I had a mild seizure, but Xanax saved the day. Otherwise it was not particularly enjoyable most of the time because I don't like stimulation. Especially towards the end, the 2C-B almost made me suicidal. But opium made that bearable as well. No detectable mental issues, luckily. I waited with the DMT until the next night, and it blew me away. That's it for this thread.

 

[sekio]

The end.