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AlphaOdure
07-10-2005, 08:54
Okay; sorry another one here. I'm interested in VALID and WORKING potenation techniques everyone uses out there to boost they're opiates.
You can include boosting opiates/opioids with more or other opioids; or other psychoactive drugs. But...

I'd prefer we focus on either opiate boosters, OR easily accessable, non-psychoactive chemicals. But all others are welcome aside from the obvious: pot, benzo's, alcohol etc. unless you've got something interesting to add.

Remember, include doses, time intervals, the substance, your tolerance and daily use, the experience, and other specifics! So be concise, to the point, and specific.

Pharmacological discussion is welcome and preferred! All you doctors, neurologists, and chemists are welcome too. Keep my use of big words in line =D

AlphaOdure
07-10-2005, 09:06
i'll go first:

i'm on 50-70 mg of dolophine or better known as methadone daily. I keep pushing up, so i'd love to be on over 100 mg, but i can't afford it right now.

I've very effectively been using cimetidine as a potenater. The drug, usually used for acid reflux, is safe in higher doses and is relatively easy on the GI tract and system.

Cimetidine comes in doses of 200 mg per pill; and are used once a day for its typical recommendation of acid reflux. But it has been used upwards of a couple grams for severe stomach problems in hospitals; including ulcer's. I found this on Rxlist, by the way.

Methadone peaks for me at about the t + 1.5 hr point from ingestion. And usually plateau's off at this time for another 2 hours. During this time i "load" on cimetidine. Dosing usually 800 mg at t + 1 hr every half hour or so for the next 2-3 hours.

Since Cimetidine is eliminated and metabolized by the same enzyme that metabolizes opioids, i usually wait for the methadone to realize its effect first; then take the booster to hinder my body in metabolizing it quickly.

The potenation effect of cimetidine is most certainly noticable IME. 800 mg will push the effects up, including the itch and nod, for about 30 minutes - 1 hour. And will certainly accumulate in the system to overall increase and lengthen the plasma levels of methadone in my blood; at least it seems so. i've never directly monitored by plasma levels.

Cimetidine does occupy the CYD enzymes that metabolize opioids (and other drugs) so be careful when using it. Liver toxcity is probably possible including jaundice, abdominal pain, and eventually cirrohsis of the liver; so use sparingly!

Cimetidine is readily available OTC. I recommend the generic version which clearly has "cimetidine" printed on it. It should be no more than $5 for at least 30 200 mg pills. Its also known as tagment HB but for a much higher cost.

who knew? tagment and opiates?

glenn420
07-10-2005, 09:29
What's potenation or a potenater?

I'm just buggin you, "potentiate" :P

AlphaOdure
07-10-2005, 09:55
^ ^ ^
thanks, will edit =D

i'm a horrible speller. But somehow i can get the drug-one's right or pretty close.

johnnyb420
07-10-2005, 11:18
diphenhydramine helps make the high a little more noddy if that is a word . i also have had luck with quinine. cimetidine as mentioned above works well also .

x0r
07-10-2005, 12:28
i'm on 75mg of methadone daily and its been about 14 months now since starting. i'd give anything to just once again feel that beautiful warm fuzzy happy feeling that only a hand full of percs can give me. i enjoy the little bit of a buzz i get from my daily meth dose but i find that if i take more or even double my dose it just makes me more tired feeling and it doesnt enhance the nice feeling that makes it enjoyable. know what i mean.. therefor the tiredness is just more of a niusence(sp).. maybe it would feel good if i drank all my 7 carries at once??

perhaps i'll try that cimetidine.. see if it works, and how it feels

johnnyb420
07-10-2005, 13:19
i hope you were kidding about taking all seven of your carry home doses having to wait a whole week to get your next dose would suck to say the least thats if you made it thru 1190mg of methadone8o


in my experiance, the cimetidine does not make the high any better just a bit longer as cimetidine competes for the same enzymes that metabolize opioids ,diphenhydramine helps make the high a little less itchy and more noddy if that is a word . i also have had luck with quinine,for both making it stronger and longer .:\

be careful with vitamin supplements as some can burn thru your dose at a faster rate and precipitate withdrawal.:(

ombladon
07-10-2005, 15:00
I was on 205mg of methadone daily for almost a year...mabye a good year actually, untill recently i decided to wean myself off, 5mg a week and right now i'm at 170mg a day, 1.5mg clonazepam 0.5mg 3x a day, and clonidine 0.1mg twice during the day in halfs and 1 and 1/2 at night, as well as newly prescribed baclofen a muscle relaxer 10mg 3x a day, all prescribed. I actually take more like 0.5mg-1mg clonazepam...around 120mg methadone a day and about 1 and 1/2 clonidines a day, b/c i save away drugs so i can get high as well about once or twice a month when ill do about 500mg methadone, 10mg clonazepam along with weed, which goes great, and if im not passed out and actually want to increase my high further ill take a bit of clonidine, under 0,1mg. I might/prob use baclofen in a combo too, i just got it a few days ago and only tried it 2ice. So more on that later...Unless u got a tolerence to methadone, u shouldnt try to potentete ur buzz. For the first 6-7 months on treatment, only methadone and clonazepam, sitill same dose clonazepam, methadone 100mg+ i nodded out hardocre every second, on chairs, sitting up that i had to be slapped awake MANY TIMES, burn holes from cigarettes smoked during these exact same nods, could have burned down the entire house MANY TIMES...all in all u won't need a potentator without tolerence :D

wastedwalrus
13-10-2005, 19:06
Grapefruit Juice works for me. It seems to increase the duration and make the high slightly better. Benzo's (although the only one I've ever tried with an opiate is xanax) works alright in my experience too. They tend to change the high a little bit but most frequently for the better.

jasoncrest
13-10-2005, 22:23
Benzos just add the high of benzos to the high of opiates, it is not potentiation...

n1 Opiate Potentiator: CLONIDINE (Catapres, Rx only)

take 0,1-0,3mg clonidine with your opiate and you will fell a stronger nod, a stronger rush (if you shoot the clonidine with your opiate, but BEWARE it's dangerous to shoot pills)

n2 Opiate Potentiator: PROMETHAZINE (or DIPHENHYDRAMINE or any other sedative anticholinergic antihistamine)

with these antihistamines you get less side effects from opiates, and they potentiate the nod

DexterMeth
14-10-2005, 00:02
^Since promethazine is not OTC most anywhere in the US, if anywhere, i'd like to point out to those who don't under what he wrote....you cant use Drammamine...i suggest BOTH types...take some of both kinds of drammamine..the yellow labled one and the purple. One is Meclazine Hcl, the other is blah i forgot how to spell it.

fishman
14-10-2005, 01:10
Dramamine is dimenhydrinate. Benadryl is diphenhydramine. Both should increase the tendencies to "nod" but not necessarily the euphoric effects. Both should also reduce any itchiness. In fact, if I don't take a small dose of Benadryl (or the OTC sleep medication Unisom, it is also diphenhydramine) I will start itching almost as soon as the heroin is up my nose and into my bloodstream, if it is any good. Furthermore, more often than not the stuff I find around a certian really-big midwestern urban area is cut with diphenhydramine in the form of "Dormin." It is used because the Dormin capsules contain a fine white powder that is easily used as a cutting agent. When I get stuff in anything greater than $10 bags (like, say, a gram), I usually get a few Dormin capsules "in case you want to cut it up, man." Needless to say, I don't want to cut it as I'll most certainly be doing it myself, and I would much rather snort the purer, tannish powder. The $10 bags are typically cut and therefore contain a much whiter powder, though the mix is so homogeneous it looks like it's all one thing. I do save a Dormin or two, nonetheless, as like I said before, it does help with the itchiness!

aphexia
14-10-2005, 05:04
diphenhydramine helps make the high a little more noddy if that is a word . i also have had luck with quinine. cimetidine as mentioned above works well also .

For codeine diphenhydramine is about the only thing that has worked for me.

I also get a bad histamine reaction at high doses (blood red eyes, red face and neck and even hives sometimes) if I dont take a strong antihistamine and this prevents that too

fishman
14-10-2005, 05:46
Also, I'd like to mention that the tricyclic antidepressant / anti-OCD medication Anafranil (clomipramine) potentiates the physiological effects of opiates. I'm a weekend user, and typically I'll do a $10 bag to start off a day/evening with no problem. Back when I was on a daily dose of clomipramine, a similar $10 bag knocked me out so hard that I aspirated into my lungs and was completely passed out for a good 4-5 hours, waking up in the hospital. BE CAREFUL WITH OPIATES AND TRICYCLIC ANTIDEPRESSANTS!

mikeylikesit
14-10-2005, 07:11
might be naive but isn't there some danger of using clonidine with opiates...
I happen to have 50 or so tbs of them but never used them....

would they be something to take with any opiate? Any saftey advice or just watch the dosage... has this stuff been used by many for this reason.. I was given to me for detox long ago..

AlphaOdure
14-10-2005, 23:34
Grapefruit juice/orange juice seems to just make me more drowsy and i really can't tell if its psychosomatic or not.

Cimetidine is more effecient in prolonging the effects. Although i must add; there is a direct correlation between opioid dose and cimetidine dose. My methadone dose has shot up so high that it seems the cimetidine isn't as effective as it used to be.

And also just a bit to add: i never take cimetidine before my daily methadone dose. This b/c of cimetidine's acidic repressive effect; it may inhibit some absorption of methadone. I don't know of any scientific evidence for this; but i've had some anecdotal, personal experience with this.

AlphaOdure
14-10-2005, 23:42
Also, I'd like to mention that the tricyclic antidepressant / anti-OCD medication Anafranil (clomipramine) potentiates the physiological effects of opiates. I'm a weekend user, and typically I'll do a $10 bag to start off a day/evening with no problem. Back when I was on a daily dose of clomipramine, a similar $10 bag knocked me out so hard that I aspirated into my lungs and was completely passed out for a good 4-5 hours, waking up in the hospital. BE CAREFUL WITH OPIATES AND TRICYCLIC ANTIDEPRESSANTS!

Really? I've used elival (if i'm not mistaken, a tricyclic) numerous times for sleep when on opioids. But more often for withdrawal. The elival literally does wonders for sleep, the shits, and over all mood. And this is at 70 mg/daily of methadone! Granted i probably never have to go more than 48 hours till my next dose even in the roughest of times; so full w/d hasn't yet set in. But still, 50 hours w/o methadone is hell. So elival works magic; its better than immodium for eliminating the shits as well.

But back to poteniating--do you or anyone else have any other experiences w/ tricyclics and opioids? Positive ones preferably? And more specifically; with elival? I've never used it for poteniating my methadone, i've used while on methadone but not for this purpose--just for sleep.

cire113
16-10-2005, 00:38
Does anyone else have experiences with using quinine to potentiate? I love drinking tonic water and lately it seems to make my opiate high betters but im not sure...

user99
16-10-2005, 01:07
Really? i got to try with Quinine then...

redfish2fish
17-10-2005, 23:03
I have great success with tonic water containing quinine. My usual routine for ingesting codeine is to take 50mg of diphenhydramine (Benadryl) and 1 gel capsule of Alka Seltzer Plus Night Time Cold about 30 minutes before taking the codeine and drink ~ a liter of tonic during the experience. This combination greatly increases the effects I achieve from codeine, though I am not sure how it may interact with other opiate-like drugs.
From opiods.org:
"Quinine and quinidine accentuate the buzz of opiates but only directly help with codeine metabolism by boosting the amount changed into morphine. Tagamet and grapefruit juice will weaken codeine substantially. The prescription antihistamine promethazine (Phenergan) helps out codeine even more, and is found with codeine in the Schedule V cough syrup Phenergan VC With Codeine. Quinine will tend to have its effect without impairing hydrocodone but does seem to burn off the buzz more quickly and may flatten the dose-to-response curve."

Paregoric Kid
17-10-2005, 23:56
yeah I've tried tonic water w/ quinine with opioids, not sure if it works though.
DXM, diphenhydramine/dimenhydrinate/other antihistamines, magnesium, baking soda (w/ methadone), loperamide, grapefruit juice (but not with methadone), prozac/other SSRIs, and of course cimetidine.
taking potentiators is a ritual for me.

Khadijah
03-05-2006, 21:33
I was wondering what the best potentiator for oxycodone was, and then I started thinking that for each opiate drug it may be different and i thought, hey why not make it a thread that people could look up all their information in, and not just oxy.

I saw a lot of potentiation threads when I searched but, none of them had much information in them and most of them were specific to one drug.

but with everyones help, this thread could be a list of the best substance to potentiate each opiate.

So, what potentiates each drug, and what would you say is the BEST option to potentiate that drug?

By potentiating, I mean a substance that when combined with the opiate, has a synergy effect and boosts the high thru chemical interaction. you could say alcohol potentiates , in the way that it makes you feel more fucked up, but I dont believe that it works the same way as say Benadryl does to interact with the opiate and increase the high.

So with that said...What potentiates:

CODEINE
-Grapefruit juice (fresh works best, do not use sweetened grapefruit drinks you need the straight juice)
-Diphenhydramine (Benadryl)
-Promethazine (Phenergan) - Take after administering codeine, high will be shortened if taken before
-Orphenadrine
-Cyclobenzaprine
-Doxylamine Succinate (Active ingredient in NyQuil)

HYDROCODONE
-Grapefruit juice
-Diphenhydramine
-Orphenadrine
-Doxylamine Succinate

MORPHINE
-Diphenhydramine

HEROIN
-Diphenhydramine
-Grapefruit Juice (May not enhance high, but will lengthen it due to enzymes inhibiting the metabolism of the drug and elongating the duration of the high.)

OXYCODONE
-Diphenhydramine
-Cimetadine (Tagamet) take one hour before your opiate

HYDROMORPHONE

MEPERIDINE

FENTANYL

OPIUM
-Cimetedine
-Propoxyphene (Darvocet)
-Diphenhydramine

METHADONE
-Cat's claw (herbal)
---------------------------

Theres always more opiates but those are the main ones to start with and feel free to add anything you have information for.

i would do research and post what I learn, but i dont know that much about brain receptors, chemistry of the drugs, the little things that would make a difference, and I dont want to post wrong information without meaning to just because I didnt understand the concept enough to know whats bullshit and whats true.

So i will leave that part of it out and hope that some of yall "smart people" answer.

Hopefully with enough knowledgeable posters this could become a thread that is the ultimate guide to potentiating opiates and maybe even become a stickyed thread if it prooves to be useful. :)

Sphinx (Afterlife)
03-05-2006, 21:41
Well...

pretty much whatevers gonna 'potentiate' one opiate is gonna do the same for any other, in the sense of the micro opioid receptor, which is prolly where your aiming to increase potency at for a 'better high'.

Ive read that supposedly Procaine+Heroin is to potentiate the effects of the rush, no clue if thats true at all though, but it has appeared in street samples, possibly just cause of convenient access to the cut (insert vision of cocaine dealer realising greater profits in heroin but still having all his procaine cut for his coke buisness left over)

Khadijah
03-05-2006, 21:59
Well what i will do is wait until there are more responses then Ill periodically edit the first post to include the information that gets posted and that way the big guide will be at the top of the page and information can keep gettin added

anyone with information for or against any potentiator should post why that shoud/shouldnt be on there and why that way we can make sure no wrong facts get in tere and the thread can be more definitive and not just hearsay

paradoxcycle....waitin on you to come with your vast knowledge....

IntralopeAMINE
03-05-2006, 22:22
GREAT THREAD
ill throw a few i know all too well out there... that most dont know


METHADONE - Cats Claw. 25%+ incease in duration using cats claw.

OPIUM and various others opiods - Propoxyphene. Ya, darvocet, its shit alone. HUGE potentiator of opium... stumbled on it years ago w/ huge supply of what i thought was useles darvies. check out its unique p450 properties along with many other pubmed discoveries.... be careful tho.... dangerous and ez drug to OD on. im talking like 1 or 2 darvies with a seriously reduced dose.

OPIUM - Cimetedine. seems to fuck with and kill other opoids (stops vicodin from metabolizing into hydromorph, etc) but it adds one hell of a kick to opium and increases duration.

ummm... magnesium is a must. always have high levels of magnesium obviously... take it with any opiate/oid. helps with absorbtion also.

SOooooooooOoOOOOOoo many prescription drugs will potientiate opiates.... mostly due to unique and strong p450 enzyme inhibition but its tricky stuff and specific to the opiate/oid your fucking around with. Then there are some that potentiate it simply due to synergy of pleasurable effects (or more generally unknown "magic" in da brain ;)
Phenergan even tho it should only potentiate because of its antihistimine properties goes beyond that. many will back me up. there is something more to antihistamines, ESPECIALLY w phenergan, than the sedation effect adding to the nod.

there are a ton of potentiators.... ill post more later. so many unknown ones too... alot of herbal shit people dont know about ta boot

if you want a REAL Ultimate Opiate Potentiation thread then somebody (ill do it eventually :) needs to post a nice bigass conclusive list of p450 enzyme inhibitors and inducers and a list of opiates/opoids and how they metabolize/how they can be modified for potentiation. its all out there on the net but nobody has ever gotten more than 50% of the real data on one page, etc etc.

Khadijah
03-05-2006, 22:35
^^Well if you will post that information i will put it in here and we can do it up right, make it the ultra mega end all and be all potentiation thread. ya down for it? ;)

I know that benadryl works for oxy and a lot of other opiates, BUT , i dont want to list it as potentiating all of them because im sure some of them it dont work for, so fill me in.

I have took Phenergan before when it was in my codeine syrup but I was on oxy....so i decided that a few tsp's of that shit would potentiate pretty good because i have heard a lot about it bein a potentiator. whats the definitive answer there?

I will keep adding any info as it comes....so hit me with all you know

Also if there is any 'catches' or knowlege that you need to know about a certain potentiator (such as, "______ works, but only if you take it more than 2 hours before your opiate") include that too and i will put it as a note so that people know not only what to use but the best way to use it.

Introspective_Johnny
03-05-2006, 23:04
Cimetidine seems to help with hydro's a little. I usually can't get high off of them anymore, but I took one tagamet hb half an hour before taking 100mg's of hydro and it seemed to give me a little bit more of a slight nod, but didn't add too much to the euphoria. This was after being without opiates for about six weeks.

redeemer
03-05-2006, 23:28
Grape fruit juice helps codeine metabolize into morphine instead of the inactive nor-codeine, the same concept happens with dihydrocodeine, hydrocodone and perhaps more, can't remember right now. It's preferred to make the juice yourself out of white grape fruits and including as much pulp as you can since a lot of the desirable enzymes are in that part of the grapefruit.

After finding out about this I never do the aforementioned opiates without grape fruit juice, I feel like I'm wasting some of the high if I don't (which I infact am).

Blind Melon
04-05-2006, 00:12
How big of a deal does the grapefruit juice make? If I have some Oxy/Hydro/whatever and I'm absolutely ready to get high is it worth the wait and effort?

Say I'm buying Norco's, (not that I illegally obtain narcotics) rather than buy one extra pill should I save the cash for some grapefruits?

Does it affect the duration and the intensity or what?

Khadijah
04-05-2006, 00:19
Updated.....

the juice does make a difference...it was a long time ago that i tried it so i dont know but its enough to notice. grapefruits aint expensive just grab one and youll get enough juice out of it.

rollEpollE
04-05-2006, 00:23
Good thread. I'm interested in the results as well.

Dancan
04-05-2006, 01:15
I think this should be made into a stick post...but there may be moral complications

redeemer
04-05-2006, 01:22
How big of a deal does the grapefruit juice make? If I have some Oxy/Hydro/whatever and I'm absolutely ready to get high is it worth the wait and effort?

Say I'm buying Norco's, (not that I illegally obtain narcotics) rather than buy one extra pill should I save the cash for some grapefruits?

Does it affect the duration and the intensity or what?
Grape fruit juice makes a world of difference to me. It extends my DHC high from about ~1.5 hours to 3-4 hours. How much it affects you will probably depend on the composition of enzymes in your body but give it a try. Grape fruits are cheap as hell anyway... at least compared to drugs.

johanneschimpo
04-05-2006, 01:36
^ Yeah, like potentiating opium with darvocet :(

Gaz_hmmmm
04-05-2006, 01:41
Marijuana will potentiate all opi's!

Grapefruit juice works for morphine, diamorphine (Heroin) and from what it seems all opi's! Though I'm not sure about methadone*!

Diphenhydramine (Benadryl) (Nytol in the UK) works well with all opi's! :)

I think Cimetedine (Tagemet) works the same way as grapefruit juice, but it's stronger. So if you have both just take the cimetedine, don't bother wasting them by taking them together!

N-methyl-D-aspartate (NMDA) receptor antagonist drugs like :-

DXM (Sub 200/150mg doses) and Ketamine seem to lower opiate tolerance and increase the effects!

PCP and Nitrous Oxide (Laughing gas/N2O) I'm not sure about though. I've had personal experience with mixing Heroin and N2O and it's really good, but I didn't notice any lowering of tolerance sadly! :\

Methadone's also an NMDA antagonist, but as we all know, it's an opioid so there's gonna be tolerance.**

*Anyone know if Grapefruit juice actually doesn't potentiate methadone? The reason been the two times I've used grapefruit juice and meth', the meth's not seems as strong as when I take it without the grapefruit juice! :\

**There is (If anyone can fish it out on PubMed) an article about lowering tolerance using Methadone (Cause of it's NMDA antagonistic properties) combined with morphine.

Vandalaay
04-05-2006, 03:45
Phenergan even tho it should only potentiate because of its antihistimine properties goes beyond that. many will back me up. there is something more to antihistamines, ESPECIALLY w phenergan, than the sedation effect adding to the nod.


^ I'll second that. A lovely combo. :)

dubmachine
04-05-2006, 03:45
after attempting to make sense of that .PDF of CYP450 inhibitors, substrates and inducers, I dreamed of something similar to this, but with the addition of what NOT to take with x drug of choice, what would you call that, depotentiators? impotentiators? lol

Khadijah
04-05-2006, 07:50
Aight updated again with some of it...the shit that peeps werent sure about i left out but keep em comin guys :)

euphoricnod
04-05-2006, 09:16
You wanna know what makes my shit more potent... and this may seem obvious but grapefruit and *drumroll* more of the drug... just my two cents K

brainiacthemaniac
04-05-2006, 09:22
You wanna know what makes my shit more potent... and this may seem obvious but grapefruit and *drumroll* more of the drug... just my two cents K

Good Point...I think Bono would agree

jasoncrest
04-05-2006, 12:48
So according to this thread, the following substances potentiate Opiates:

#Antihistamines
(promethazine, cyclizine, diphenhydramine.....)

#CYP enzymes inhibitors:
(cimetidine, grapefruit juice...)

#NMDA antagonists
(cat's claw, ketamine, DXM, etc....)

#Muscle-relaxants
(carisoprodol/Soma, cyclobenzaprine, orphenadrine...)

#Other CNS depressants
(benzos, alcohol...)

There's also quinine.

Are there any other potentiators??

Most of them are listed here:
http://opioids.com/opiates/index.html
(best opiate potentiation webpage, with almost nothing missing)

dnbmassive
04-05-2006, 14:12
tagamet will ruin the metabolization of codeine to morphine

Khadijah
04-05-2006, 16:08
aight its edited and updated with some new shit

smartshop
04-05-2006, 16:32
don't forget ibogaine. I've seen information from the french company that sold ibogaine long time ago, and it mentiones that opiate analgesia is potentiated. Mind you these pills contained 15 milligrams (if i am not mistaken), not 2 grams as in detox treatments.

OpiatesRus
04-05-2006, 18:38
this thread is rolling
great job =D
I'm on morphine and perc and hydro w/ xanax. & White Grapefruit Juice and some Benedryl. ;)

I'm nodding my ass off
peace peeps8) %)

OCjunky
04-05-2006, 18:57
Nice thread guys. I find that Atarax which is an anti-histamine, potentiates any opiate very nicely, just as well as prometh or even better, i highly suggest it....


RANDOM NEWS: Hey i just got my 2006 PDR and it says that they are still making Oxycontin 160's, whats up with that guys?

Limpet_Chicken
04-05-2006, 19:15
Taking promethazine with codeine, be sure to wait for the codeine to fully come on, as promethazine is a CYP-P4502D6 substrate, and will inhibit metabolism of codeine to morphine to quite a noticeable extent.

DXM is also a CYP2D6 substrate, and in this case, I wouldn't take any but a very small dose with codeine, as it will inhibit the metabolism of DXM, if taken after the codeine, and inhibit the demethylation of codeine, if taken before.

Papaverace
04-05-2006, 20:35
...Grapefruit juice works for morphine, diamorphine (Heroin) and from what it seems all opi's! Though I'm not sure about methadone...

Different views about that for sure. In my opinion Bicarbonate of soda and grapefruitjuice and possibly cat's claw, are all working.


...Anyhow here is an experiment that says methadone levels increase:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15229464&dopt=Citation

Khadijah
04-05-2006, 23:43
Taking promethazine with codeine, be sure to wait for the codeine to fully come on, as promethazine is a CYP-P4502D6 substrate, and will inhibit metabolism of codeine to morphine to quite a noticeable extent.

DXM is also a CYP2D6 substrate, and in this case, I wouldn't take any but a very small dose with codeine, as it will inhibit the metabolism of DXM, if taken after the codeine, and inhibit the demethylation of codeine, if taken before.


Thanks for the info, but could you please put that in words so that a non chemist could understand it? I would love to update the thread and use that info in the original post but...i cant understand a fuckin word of it past CYP-.....=D

It seems like youre a really knowledgeable person but sometimes forget that not everone else has the schooling you did or knoweldge of that shit...I for one have no fuckin clue what a substrate is, much less a CYP-P4502D6 substrate. or what demethylation is, etc. im sure other people on the site do know but i think its safe to say the average person dont and my goal here is to give useful easy to understand information so....ya know...

help a sista out...:)

chokinvictim
05-05-2006, 06:23
Lacey K, you have grapefruit juice listed under codeine, but according to the link posted (http://opioids.com/opiates/index.html), "Tagamet and grapefruit juice will weaken codeine substantially."


edit:
While searching some old threads, I found another interesting comment:

"With Codeine, you want a CYP2D6 inducer and a CYP3A4 inhibitor. Most CYP2D6 inducers (what you want) are also CYP3A4 inducers (what you do not want...).
These substances don't potentiate Codeine...
Carbamazepine is a CYP2D6 inducer, so more Codeine is converted to Morphine
BUT is is also a strong CYP3A4 inducer, so it clears the Codeine/Morphine very quickly from your system..."

Codeine has to be converted to morphine. However, the substances that help convert codeine to morphine also get the morphine out of your system faster????