JohnBoy2000
Bluelighter
- Joined
- May 11, 2016
- Messages
- 2,465
Well, reduce it, at least.
I've tried Prozac, lexapro and mirtazipine, but effexor was the only one to have this effect.
First day I took it, I had a little constipation, but thereafter no issues.
And from then on, my stomach seemed to have a better ability to retain food.
But previously, I would have to use the bathroom like, 4 to 5 times, before lunch alone.
Anyways, I'll be modifying effexor shortly, but I'm curious as to what element of effexor specifically relieved my IBS, so I can look for that element in a future medication.
Does effexor have anti-cholinergic properties to some extent?
One day, I also experienced dry mouth, which lasted for about an hour, and then never again, before or since, and again, this only happened on effexor.
I was under the impression it acts mainly on serotonin, and to one thirtieth the extent, noradrenaline.
Does it have to some minor extent an effect on the aciticholine receptor also?
What about it's mechanism of action would alleviate diarrhea??
From wiki:
"Venlafaxine is usually categorized as a serotonin-norepinephrine reuptake inhibitor (SNRI), but it has been referred to as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).[56][57] It works by blocking the transporter "reuptake" proteins for keyneurotransmitters affecting mood, thereby leaving more active neurotransmitters in the synapse. The neurotransmitters affected areserotonin and norepinephrine. Additionally, in high doses it weakly inhibits the reuptake of dopamine,[58] with recent evidence showing that the norepinephrine transporter also transports some dopamine as well, since dopamine is inactivated by norepinephrine reuptake in the frontal cortex. The frontal cortex largely lacks dopamine transporters, therefore venlafaxine can increase dopamine neurotransmission in this part of the brain.[59][60]Venlafaxine indirectly affects opioid receptors (mu-, kappa1- kappa3- and delta-opioid receptor subtypes) as well as the alpha2-adrenergic receptor, and was shown to increase pain threshold in mice. When mice were tested with a hotplate analgesia meter (to measure pain), both venlafaxine and mirtazapine induced a dose-dependent, naloxone-reversible antinociceptive effect following intraperitoneal injection. These findings suggest venlafaxine's seemingly superior efficacy in severe depression as opioids become increasingly used as a measure of last resort for refractory cases"
Very interestingly, I see venlafaxine effects some opioid receptors??
I'm just learning of this now for the first time.
I think wiki must have been recently updated with that information cause, I don't recall reading it there before.
Do tricyclics (which I'll be graduating to I imagine), carry any "downstream", or upstream, for that matter, effects on opioid receptors??
But yeah - it makes no mention of any anticholinergic properties, which is what I would imagine would lend itself to relief from persistent diarrhea...?
I've tried Prozac, lexapro and mirtazipine, but effexor was the only one to have this effect.
First day I took it, I had a little constipation, but thereafter no issues.
And from then on, my stomach seemed to have a better ability to retain food.
But previously, I would have to use the bathroom like, 4 to 5 times, before lunch alone.
Anyways, I'll be modifying effexor shortly, but I'm curious as to what element of effexor specifically relieved my IBS, so I can look for that element in a future medication.
Does effexor have anti-cholinergic properties to some extent?
One day, I also experienced dry mouth, which lasted for about an hour, and then never again, before or since, and again, this only happened on effexor.
I was under the impression it acts mainly on serotonin, and to one thirtieth the extent, noradrenaline.
Does it have to some minor extent an effect on the aciticholine receptor also?
What about it's mechanism of action would alleviate diarrhea??
From wiki:
"Venlafaxine is usually categorized as a serotonin-norepinephrine reuptake inhibitor (SNRI), but it has been referred to as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).[56][57] It works by blocking the transporter "reuptake" proteins for keyneurotransmitters affecting mood, thereby leaving more active neurotransmitters in the synapse. The neurotransmitters affected areserotonin and norepinephrine. Additionally, in high doses it weakly inhibits the reuptake of dopamine,[58] with recent evidence showing that the norepinephrine transporter also transports some dopamine as well, since dopamine is inactivated by norepinephrine reuptake in the frontal cortex. The frontal cortex largely lacks dopamine transporters, therefore venlafaxine can increase dopamine neurotransmission in this part of the brain.[59][60]Venlafaxine indirectly affects opioid receptors (mu-, kappa1- kappa3- and delta-opioid receptor subtypes) as well as the alpha2-adrenergic receptor, and was shown to increase pain threshold in mice. When mice were tested with a hotplate analgesia meter (to measure pain), both venlafaxine and mirtazapine induced a dose-dependent, naloxone-reversible antinociceptive effect following intraperitoneal injection. These findings suggest venlafaxine's seemingly superior efficacy in severe depression as opioids become increasingly used as a measure of last resort for refractory cases"
Very interestingly, I see venlafaxine effects some opioid receptors??
I'm just learning of this now for the first time.
I think wiki must have been recently updated with that information cause, I don't recall reading it there before.
Do tricyclics (which I'll be graduating to I imagine), carry any "downstream", or upstream, for that matter, effects on opioid receptors??
But yeah - it makes no mention of any anticholinergic properties, which is what I would imagine would lend itself to relief from persistent diarrhea...?
