Not at all. I was on Zoloft (sertaline) for months and smoked down on CBD dominant weed all the time (helps with anxiety) and ingested my fair share of CBD edibles while on Zoloft. I would not worry. I was extremely worried about this shit when I first got on it, but I talked to my doctors about it and they said "unfortunately you can smoke all the weed in the world on Zoloft". But yea CBD doesn't really produce any feelings of euphoria IME (unlike weed) so I would not be worried about seratonin syndrome. I've done so many drugs on Zoloft (coke, xanax, opiates, mushrooms to name a few) and had little to no reaction.