No, it will just make you high on cocaine as well. Though, what you put in the IV will matter to what happen when you mix, and I am assuming you mean an depressant of some kind (heroine, opium, or a prescription opioid). Which, if that is so, yes it can help take out some of the tiredness and "wake you up", and it can help negate some of the depressant effects. Yet, in reality, you are just high on both substances.
If it was heroine or an opioid of any kind, Narcan can help. It binds to the same receptors as opioids, and prevents the opioid from being able to bind (as a competitive antagonist). This doesn't exactly make you "come down", but it can do some good to stop the rest of the opioids, as well as help stop/prevent SOME effects of an overdose.