It is not very long ago when SNRI were introduced as antidepressants, in our country only about 10 years. I am interested in why well known SNRI - DXM - was not introduced as antidepressant long time ago? Was it due to the lack of interest for pharmaceutical companies to research DXM in depth, or there were scientific studies and SNRI antagonism of DXM was noticed not to influence depression, either too much side effects at needed dosage were noticed. Where is the truth, money or science? Or maybe SNRI in not the answer to the depression treatment?