Very interesting post as always. I do recall Burroughs's writing on the subject now that you mention it.
Anecdotally; there are some individual differences at play as well. As from my personal experience some people get very little in the way of a rush with oxycodone. Where as others find it to have a good rush. Personally I found the it to have 0 rush even when sick as hell.
Very strange. I'm pretty sure it's the only opioid that I don't get a rush from actually if I think on it. Well at least out of what I've had the pleasure of consuming; that is. :D
As an anecdotal example I tried really fucking hard to get one off oxycodone. At one point when my tolerance was relatively high I had friends hit me with 6 shots of oxycodone. The first 4 where basically at once. Then next 2 followed 30 seconds to a minute later.
We didn't have luer lock with a large enough barrel available at the time. I'd used the last one on micron filtering the oxycodone for the shot in the first place. I didn't have a tip for the barrel either. That & actually IIRC I used two 3ml barrels filtering. As such the need for the six 1ml needles. Due to oxycodone's limited solubility in water; that is. On
PubChem I'm coming up with 166mg/ML.
As such I want to point out that doing something like I did above is really fucking stupid & don't take it as an endorsement of doing stupid shit like that. I had the tolerance at the time but regardless. Thanks.
Continuing the story; I was relatively sick at the time. As I usually only get a rush from opioids when sick. I had them hit me in both arms at the same time. Something I obviously couldn't do myself. With my tolerance it necessitated such a large dose. Again a reminder this is like a gram of oxycodone equivalent to a similar amount of morphine for reference. In other words don't do this yourself.
I still did not get a "rush" in my opinion. Where as I do get a good to great rush from morphine. A great rush from say hydromorphone, oxymorphone or diacetylmorphine. To name a few examples.
Though based on my group of "friends" at the time; I was the exception. Most got a rush from oxycodone. A few found it meh. I was the only one I knew that found it to have no rush whatsoever.
So I wonder if there isn't some individual body chemistry or other factor at play as well.