aced126
Bluelighter
- Joined
- May 18, 2015
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They could've provided more good information on the binding to the protein.
In acidic conditions, N-acetylaziridine decomposes. The N gets protonated (its lone pair has more s character to compensate for ring strain, hence why also N-acetyl aziridine is not planar as it is less conjugated with the C=O bond.
However in basic conditions it seems that deprotonation of the nitrogen after the acylation has occured gives a stable N-methyl-aziridine.
Am I missing something?
In acidic conditions, N-acetylaziridine decomposes. The N gets protonated (its lone pair has more s character to compensate for ring strain, hence why also N-acetyl aziridine is not planar as it is less conjugated with the C=O bond.
However in basic conditions it seems that deprotonation of the nitrogen after the acylation has occured gives a stable N-methyl-aziridine.
Am I missing something?