First Bad Comedown
Bluelighter
- Joined
- Nov 26, 2010
- Messages
- 562
In my opinion, the term 'overdose' should not apply to MDMA.
With most drugs, the term is used to indicate an adverse event that would normally not occur at lower doses.
Seizing, foaming at the mouth, heart-attack, stroke, liver and renal failure, even plain tachycardia and anxiety could be considered signs of an 'overdose'.
With heroin people stop breathing, but the more extreme reactions can be seen in stimulant users up to and including brain damage.
MDMA is arguably producing minor brain 'damage' with every dose, whether it is small or not.
But even large doses normally fail to cause death.
And that singular fact allows a generation of drug users to consume TOXIC doses of MDMA without regard to the real consequence - permanent alterations to brain serotonin function.
Just because a person can take a GRAM in a night and not seize up does NOT mean an overdose didn't occur.
If you were able to witness the destruction of axons you might agree.
And when a person takes a normal dose and ends up in the ER, what do we say then?
Its not like a crack or meth addict that took too many doses - there are many variables that influence MDMA's toxicity.
Body temperature and dosage are indeed critical, but some people get fucked or killed on otherwise typical doses.
The pharmacokinetics of MDMA are quite complex - but it is known that each subsequent dose causes a greater and greater plasma concentration.
And therefore brain exposure.
If the first dose is the most powerful in terms of its effects, why bother re-dosing when it actually does more damage?
By this logic, re-dosing is ALWAYS an overdose.
With most drugs, the term is used to indicate an adverse event that would normally not occur at lower doses.
Seizing, foaming at the mouth, heart-attack, stroke, liver and renal failure, even plain tachycardia and anxiety could be considered signs of an 'overdose'.
With heroin people stop breathing, but the more extreme reactions can be seen in stimulant users up to and including brain damage.
MDMA is arguably producing minor brain 'damage' with every dose, whether it is small or not.
But even large doses normally fail to cause death.
And that singular fact allows a generation of drug users to consume TOXIC doses of MDMA without regard to the real consequence - permanent alterations to brain serotonin function.
Just because a person can take a GRAM in a night and not seize up does NOT mean an overdose didn't occur.
If you were able to witness the destruction of axons you might agree.
And when a person takes a normal dose and ends up in the ER, what do we say then?
Its not like a crack or meth addict that took too many doses - there are many variables that influence MDMA's toxicity.
Body temperature and dosage are indeed critical, but some people get fucked or killed on otherwise typical doses.
The pharmacokinetics of MDMA are quite complex - but it is known that each subsequent dose causes a greater and greater plasma concentration.
And therefore brain exposure.
If the first dose is the most powerful in terms of its effects, why bother re-dosing when it actually does more damage?
By this logic, re-dosing is ALWAYS an overdose.
