Esketamine/S-Ketamine: 2x potency of racemic K, clearly more DRI action, clearer psychedelic dissociation with antidepressant, sedative, and anxiolytic properties IMO/E.
Racemic Ket: Can be more "relaxing" in a amnesic, wonky sense with some more complexity to the hallucinogenic properties.
Methoxetamine: Definitely more potent and longer-lasting than Ket, but certainly more psychedelic and serotogenic with an opioid-reminiscent warmth and antidepressant properties. This one can get very deep. It is my favorite arylcyclohexylamine and my DOC (when I could find HQ white crystalline MXE)
I've seen people have panic attacks on dissociatives/ACH's (i.e. K) and I've seen some experience euphoria and anxiolysis on ACH's. Just really depends on your reaction to the dissociative experience, some can't handle it or get scared, it can be very intense not in a classic psychedelic sense either, much stranger than those.
Arylcyclohexylamines contain some of my favorite compounds for recreational, as well as therapeutic (AD and anxiolytic) effects at threshold doses that can be used functionally for me. A benzodiazepine will always be better in terms of a panic attack though. BZD's increase the efficiency of synaptic transmission of the neurotransmitter GABA by acting on its receptors. GABA responsible for lowering of inhibitions and anxiety-relief.