JohnBoy2000
Bluelighter
- Joined
- May 11, 2016
- Messages
- 2,468
Talking specifically combination of enzyme inhibitors, with enzyme substrates.
Cmax can triple or even quadruple, area under the curse increases exponentially - but it's noted that no dose reductions are necessary.
I get the answer - "there's no simple answer" - but, just to garner some degree of insight?
How could that possibly be the case?
Specifically I'm talking Atomoxetine with an SSRI like paroxetine or fluoxetine.
Plasma levels go way way up, but supposedly don't impact clinical outcome.
So - it's obvious not directly like taking 3 or 4 times the dose of the inhibited drug so - what then?
Is there a way to find some kind of an answer to this question?
Cmax can triple or even quadruple, area under the curse increases exponentially - but it's noted that no dose reductions are necessary.
I get the answer - "there's no simple answer" - but, just to garner some degree of insight?
How could that possibly be the case?
Specifically I'm talking Atomoxetine with an SSRI like paroxetine or fluoxetine.
Plasma levels go way way up, but supposedly don't impact clinical outcome.
So - it's obvious not directly like taking 3 or 4 times the dose of the inhibited drug so - what then?
Is there a way to find some kind of an answer to this question?