what drugs are safe to use on sodium valproate?

[dragonxninjaxpowa]

Bitter orange inhibits some liver enzymes so im not sure. It might be best to avoid that one. Or hammilton might have a better idea if it would be safe to use or not.

He knows more then me in either case.

grrrr, really have to get these meds changed then. as there must be other types of meds that cover all seizure types like sodium valproate does.
hopefully they will get changed eventually, but i may be waiting weeks or even months before that happens.

i cross my fingers that i get onto pregabalin, thats whether it's suitable for the type of seizures i have and whether the side effects are not dreadful on it.
as i read up and that goes with most things and is like a recreational drug by itself.
so can only wait till i see the specialist in a few weeks then and hope for the best.

for now i guess only weed and blue lotus, nothing alse ok, if so, please let me know?

 

[paranoid android]

grrrr, really have to get these meds changed then. as there must be other types of meds that cover all seizure types like sodium valproate does.
hopefully they will get changed eventually, but i may be waiting weeks or even months before that happens.

i cross my fingers that i get onto pregabalin, thats whether it's suitable for the type of seizures i have and whether the side effects are not dreadful on it.
as i read up and that goes with most things and is like a recreational drug by itself.
so can only wait till i see the specialist in a few weeks then and hope for the best.

for now i guess only weed and blue lotus, nothing alse ok, if so, please let me know?

Bitter orange apparently inhibits P450 3a4 which is the same liver enzyme grapefruit juice inhibits. I don't know if it inhibits any other enzymes along with this one or not. Bitter orange can also lower the seizure threshold itself since it contains synephrine which acts as a stimulant somewhat like ephedrine. So id avoid it regardless.

All anti-convulsants carry some side effects it's just some are worse then others. Valproate is a good anti-convulsant but has major drawbacks. Still it's a good drug and there are drugs out there with worse side effects. If it had worked for my bipolar id still be on it.

Carbamazepine is another strong anti-convulsant but that has some nasty side effects as well. It made me sicker then ive ever been in my damn life and i know a few other people to get bad reactions from it but it does work for alot of people. Carbamazepine is a enzyme inducer though so it will make alot of drugs much less effective.

There are other but they all have draw backs and can interact with different drugs. I don't think lyrica is a very strong anti-convulsant so i doubt you would be able to use it on it's own.

 

[fastandbulbous]

Yes, they are very similar. Even the FDA doesn't bother to put any effort into distinguishing the valproates. But they're different enough to mention. They metabolize into the same substance, but the way they're metabolized by the P450 isozymes can be very different.

Eh, salts of valproic acid become the free valproic acid as soon as they hit the stomach as hydrochloric acid + sodium valproate = sodium chloride & valproic acid, so it's the identical compound before it's even absorbed into the bloodstream

 

[toe]

i'm more concerned about interactions with sodium valproate than the drugs giving me seizures. as if it gives me seizures, ill know not to do that one again.
but don't want some horrible interaction and end up unconscious, in hospital,coma or dead.

But how are you going to ensure that result of the seizure isn't coma or death?

I would strongly suggest trying to get on another anti-epileptic drug. Especially since epilepsy is the disease you're trying to treat, a fact which appears to have been lost on several previous posters. As I'm sure you know, the immediate life-threatening consequences of fooling around with your serum levels are different for epileptics than they are for those with bipolar disorder*.



*With much love to my mood-swingin' brethern.

 

[dragonxninjaxpowa]

But how are you going to ensure that result of the seizure isn't coma or death?

I would strongly suggest trying to get on another anti-epileptic drug. Especially since epilepsy is the disease you're trying to treat, a fact which appears to have been lost on several previous posters. As I'm sure you know, the immediate life-threatening consequences of fooling around with your serum levels are different for epileptics than they are for those with bipolar disorder*.



*With much love to my mood-swingin' brethern.

i guess for now till i hopefully get to change meds... just blue lotus and weed i'll do...

would things like kanna, damiana, dagga be ok too? as in not cause interactions with sodium valproate? or lower my seizure threshold?

just would like to get a legal smoking blend, so i'll have something at least till i change meds.

 

[dragonxninjaxpowa]

also i found two smoking mixes that list all the ingredients.

anyone alse on sodium valproate be kind/useful enough to tell me whether any of these ingredients would interact or not?

even better if they tried either of those smoking blends.

sense- legal smoking mix:

Ingredients: Scullcap extract, Kanna extract, Blue Lotus extract, Wild Dagga extract, Mexican Tarragon extract, Red Raspberry Leaf, Dream Herb extract, Verbascum Thapsis, Leonurus Sibiricus extract, Jasmine Flower.

p.e.p spice original:

Ingredients:
Damiana, Wild Lettuce, Skullcap, Motherwort, Red Clover, Marshmallow, Blue Lotus, Baybean, Pink Lotus, Dwarf Skullcap, Indian Warrior, Lion’s Tail, Maconha Brava, White Lotus, Siberian Motherwart, Vanilla & Honey.


as when i go out with friends i can't risk smoking weed in certain public places, as some are swarming with police.

which leaves me with no other options than smoking blue lotus with earth impact ( wild lettuce, marshmallow, red clover and rose) as a mixer instead of tobacco.

UNLESS one of those smoking mixes is ok to smoke whilst i'm on sodium valproate, too.

 

[toe]

I found this at rxlist.com

Drugs that affect the level of expression of hepatic enzymes, particularly those that elevate levels of glucuronosyltransferases, may increase the clearance of valproate.

.

Anything which falls under this category may require an adjustment in your Depakote dosage, and should probably be avoided altogether.

As well as this:

Valproate has been found to be a weak inhibitor of some P450 isozymes, epoxide hydrase, and glucuronosyltransferases.

Levels of drugs metabolized by these enzymes may be dangerously increased when they are co-administered with Depakote.

Unfortunately, rxlist doesn't keep a database on the metabolism of ingredients in Spice. That's where you're going to have to put in some detective work.

One nice thing is that (unlike with many drugs) smoking itself doesn't appear to affect the metabolism of Depakote.

 

[Hammilton]

als
sense- legal smoking mix:

Ingredients: Scullcap extract, Kanna extract, Blue Lotus extract, Wild Dagga extract, Mexican Tarragon extract, Red Raspberry Leaf, Dream Herb extract, Verbascum Thapsis, Leonurus Sibiricus extract, Jasmine Flower.

p.e.p spice original:

Ingredients:
Damiana, Wild Lettuce, Skullcap, Motherwort, Red Clover, Marshmallow, Blue Lotus, Baybean, Pink Lotus, Dwarf Skullcap, Indian Warrior, Lion’s Tail, Maconha Brava, White Lotus, Siberian Motherwart, Vanilla & Honey.QUOTE]

I don't know anything about 'sense' but SPICE contains nothing listed. Well, mugwort is used as a base. Tocopherols are loaded in there heavily as well.

I'm 99% certain it contains JWH-018 or 81 (the two I've had much). Most who have had 18 and Spice will say they're identical or nearly identical.

I'd be careful about this, just because no one is entirely sure how it's metabolized in humans.

 

[TumajNuri]

I once drank a few shots of alcohol while being on Depakine (600mg I guess). All I remember is puking, being unable to walk due to an intense vertigo. The pills weren't actually prescribed by doctor. I got them from a friend according to what he said, Depakine could potentiate the effect of other drugs which is true imo.

 

[dopamimetic]

I was put on sodium valproate *600-900mg) some years ago, yet for a suspicted manic episode*, not epilepsy so experimentation was ... less dangerous.

Remember cigarettes to be really, really fun. Big grin on your face and getting floored fun. Dissociatives to be strangely potentiated. And me getting horribly sick after some months, with half of my hair falling out etc...

* triggered by the same stupid doc quitting my memantine regimen cold-turkey and there was some 3-meo-pcp involved. So your mileage may vary.

 

[Drag2019]

Sodium Valproate is like a last resort. It's literally got some of the worse side-effects compared to other alternatives. I personally think it should only be used if all other options are not working.