SpiralusSancti
Bluelighter
- Joined
- Feb 2, 2023
- Messages
- 2,301
How often two or more drugs is significantly worse in combo then each alone?
I have a hunch that many usual drug combos are. One kinda unexpected example know rather good is alcohol + cigarettes is worse than each one alone. Why and by what extent exactly it’s hard to estimate but it’s fact/definitely statistically significantly less harmful to do just one at a time. It’s a fact that coke is worse with alcohol, even worse than ethylcocaine alone (studies on animals are quite conclusive and it’s almost sure it’s same for humans). Than, take MDMA, everyone knows how bad it’s with alcohol but do you know it’s bad with, wait for it CAFFEINE, it raises body temperature significantly, if my memory serves me good, it’s about 1 Celsius, and everyone knows fever is NOT GOOD FOR YOUR BRAIN! I kinda like this combo, used to drink a cup of coffee with M as it otherwise it can get me into melting from pleasure state from solid dose when sometimes I want that intensity but to stay active. From 125mg, nah you are good, but from 250 - 300mg of pure MDMA will render you a high, that’s most certainly too intense for most social events, but even coffee can change that. Still wouldn’t recommend it if people around you dose 125mg as amount of….ehh….entheogenic effects might be disproportional. Speed works just as good or even better, but you need just a tiny amount if you dose that high, if doing smaller dose you can mix it almost 50/50 for a waaaaay longer experience, really modified and more intense in one way and less intense in another compared to dose of MDMA alone! Kinda same for meth, except you it’s better to keep dose very low in any case. With numbers I see today and prevalence of 225 – 260mg pills I sometimes think, what the fucking fuck. First pill I took was 90 – 115 rage pill and it was it, beautiful, fucking intense, life changing roll. Took it another once a that dose and few times 1 or 1.5 and than hour latter one more pill, well fuck meeeeeeee, that was BRUTALLY intense. Real MDMA and mehDMA aside, pills are in upper strong level and heavy for some skinny girl. And guess what, loads of people will take more than one, same as with low – medium dosed pills (70 – 130), or strong pills (140 – 180) and many will pop few or more than a few during night, WTF!? That’s how you get people who combine MDMA with alcohol, downers and opiates, energy drink and some even cocaine as in monster doses it’s some kinda of monster high. Many of that doses are BAD. And look at some other trend in pills, “dirty pills” are RARE! And by dirty I mean one with caffeine, ampthetamine, meth and arguably for some even MDA. Why? Not because people like MDMA by itself best, o now. Even those who strongly consider HARM REDUCTION at least combine it with weed, psychedelics or disssos or at least use something after most of the effects are gone and that way it’s much easier to use MDMA more often as comedown is easier and Monday blues is rare for someone who’s a stoner during week. Hope you get where I’m going with this? It’s a huge problem with otc supplements and all kind of remedies as lot of people is stacking and even less chemically, pharmacologically, neurobiologically and otherwise similary impaired rarely can stack 10 usual supplements of any kind and use without disregarding for important reason why not to combine A and B or at the very least why you have to adjust dose, dosing schedule or whatever parameter to avoid some kind of damage but LUCKILY there’s not many nootropic combos that’ll lead to serotonin syndrome, paradoxical effects, potentateon in odder of magnitude and such things and when there is, meh, you might not even notice but with drugs it’s a lot more often if something like that or similar happens with some multi drug combo, you might be fucked.
I have a hunch that many usual drug combos are. One kinda unexpected example know rather good is alcohol + cigarettes is worse than each one alone. Why and by what extent exactly it’s hard to estimate but it’s fact/definitely statistically significantly less harmful to do just one at a time. It’s a fact that coke is worse with alcohol, even worse than ethylcocaine alone (studies on animals are quite conclusive and it’s almost sure it’s same for humans). Than, take MDMA, everyone knows how bad it’s with alcohol but do you know it’s bad with, wait for it CAFFEINE, it raises body temperature significantly, if my memory serves me good, it’s about 1 Celsius, and everyone knows fever is NOT GOOD FOR YOUR BRAIN! I kinda like this combo, used to drink a cup of coffee with M as it otherwise it can get me into melting from pleasure state from solid dose when sometimes I want that intensity but to stay active. From 125mg, nah you are good, but from 250 - 300mg of pure MDMA will render you a high, that’s most certainly too intense for most social events, but even coffee can change that. Still wouldn’t recommend it if people around you dose 125mg as amount of….ehh….entheogenic effects might be disproportional. Speed works just as good or even better, but you need just a tiny amount if you dose that high, if doing smaller dose you can mix it almost 50/50 for a waaaaay longer experience, really modified and more intense in one way and less intense in another compared to dose of MDMA alone! Kinda same for meth, except you it’s better to keep dose very low in any case. With numbers I see today and prevalence of 225 – 260mg pills I sometimes think, what the fucking fuck. First pill I took was 90 – 115 rage pill and it was it, beautiful, fucking intense, life changing roll. Took it another once a that dose and few times 1 or 1.5 and than hour latter one more pill, well fuck meeeeeeee, that was BRUTALLY intense. Real MDMA and mehDMA aside, pills are in upper strong level and heavy for some skinny girl. And guess what, loads of people will take more than one, same as with low – medium dosed pills (70 – 130), or strong pills (140 – 180) and many will pop few or more than a few during night, WTF!? That’s how you get people who combine MDMA with alcohol, downers and opiates, energy drink and some even cocaine as in monster doses it’s some kinda of monster high. Many of that doses are BAD. And look at some other trend in pills, “dirty pills” are RARE! And by dirty I mean one with caffeine, ampthetamine, meth and arguably for some even MDA. Why? Not because people like MDMA by itself best, o now. Even those who strongly consider HARM REDUCTION at least combine it with weed, psychedelics or disssos or at least use something after most of the effects are gone and that way it’s much easier to use MDMA more often as comedown is easier and Monday blues is rare for someone who’s a stoner during week. Hope you get where I’m going with this? It’s a huge problem with otc supplements and all kind of remedies as lot of people is stacking and even less chemically, pharmacologically, neurobiologically and otherwise similary impaired rarely can stack 10 usual supplements of any kind and use without disregarding for important reason why not to combine A and B or at the very least why you have to adjust dose, dosing schedule or whatever parameter to avoid some kind of damage but LUCKILY there’s not many nootropic combos that’ll lead to serotonin syndrome, paradoxical effects, potentateon in odder of magnitude and such things and when there is, meh, you might not even notice but with drugs it’s a lot more often if something like that or similar happens with some multi drug combo, you might be fucked.
