BigTrancer
Bluelight Crew
- Joined
- Mar 12, 2000
- Messages
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WARNING: Aurorix/Moclobemide and MDMA - aka "Perma-roll"
WARNING to users of MDMA:
It has been brought to my attention that currently in Melbourne there is at least one person, or group of people, selling tablets of Aurorix (150mg or 300mg doses of Moclobemide).
IDENTIFICATION:
Aurorix 150 mg - pale yellow, oval, cylindrical, biconvex, scored tablet, imprinted "ROCHE 150".
Aurorix 300 mg - white to yellowish white, oval, cylindrical, biconvex, scored tablet, imprinted "ROCHE 300".
These tablets are being sold with the purpose of being taken with MDMA to "increase the peak". This is extremely hazardous practice, and I would strongly recommend against taking Aurorix and MDMA in synergy for the following reason:
Aurorix acts a MonoAmine Oxidase Inhibitor.
Strictly speaking, Aurorix - or rather its active ingredient moclobemide - is an antidepressant that affects the monoaminergic cerebral neurotransmitter system as a reversible inhibitor of monoamine oxidase of type A (RIMA). The metabolism of dopamine, norepinephrine and serotonin is decreased by this effect, and this leads to increased extracellular concentrations of these neuroaltransmitters.
From Aurorix information:
Also avoid taking in combination with SSRI antidepressants or tricyclic antidepressants.
Here is a post from the Australia/Asia/NZ/Middle East Drug Discussion Archive detailing what is IMHO a case of typical non-fatal serotonin syndrome effects related directly to the combination of Aurorix and MDMA: Aurorix & E....WARNING!!
Another post, more recently added to Health Q&A Forum details an experience of serotonin syndrome related directly to the combination of Aurorix and MDMA, and follows on to the longer term effects: Did serotonin syndrome permanently ruin my brain? - update
Continuing the discussion of contraindications:
Please note: Mixed overdoses with moclobemide (e.g. with other CNS-acting drugs) could be life-threatening. Therefore, patients should be hospitalised and closely monitored so that appropriate treatment may be given. Do not be afraid to call an ambulance and tell the paramedics exactly what the person has ingested.
If you choose to blatantly ignore the above advice, and take it upon yourself to experiment with combinations of MDMA and MAOI, please take absolute minimum doses (ie. less than half of a 300mg Aurorix, less than half of a MDMA pill), avoid redosing if you aren't satisfied with the effect, and have a SOBER friend present who is prepared to call an ambulance immediately you notice the slightest difficulty. Often MDMA pills seem to have a large 'safety margin' but this is effectively removed when taken in synergy with MAOIs, making the chance for causing yourself harm far greater.
BigTrancer
[Edit: Changed title to include the street term "perma-roll" (29-10-03). Evidently this potentially fatal combination is becoming more popular lately in Melbourne, this warning needs to be spread as much as we can. BT]
Fixed formatting
WARNING to users of MDMA:
It has been brought to my attention that currently in Melbourne there is at least one person, or group of people, selling tablets of Aurorix (150mg or 300mg doses of Moclobemide).
IDENTIFICATION:
Aurorix 150 mg - pale yellow, oval, cylindrical, biconvex, scored tablet, imprinted "ROCHE 150".
Aurorix 300 mg - white to yellowish white, oval, cylindrical, biconvex, scored tablet, imprinted "ROCHE 300".
These tablets are being sold with the purpose of being taken with MDMA to "increase the peak". This is extremely hazardous practice, and I would strongly recommend against taking Aurorix and MDMA in synergy for the following reason:
Aurorix acts a MonoAmine Oxidase Inhibitor.
Strictly speaking, Aurorix - or rather its active ingredient moclobemide - is an antidepressant that affects the monoaminergic cerebral neurotransmitter system as a reversible inhibitor of monoamine oxidase of type A (RIMA). The metabolism of dopamine, norepinephrine and serotonin is decreased by this effect, and this leads to increased extracellular concentrations of these neuroaltransmitters.
From Aurorix information:
What this basically boils down to is that the risk of (the potentially fatal) serotonin syndrome is markedly increase with the use of Aurorix - to combine the use of Aurorix with MDMA could undoubtedly increase the peak intensity, however the risk of serotonin syndrome is far too great to accept this as a method of potentiating MDMA effects.In patients receiving moclobemide, the additional use of other drugs that enhance serotonin, such as many other antidepressants, particularly in multiple drug combinations, should be done with caution. This is particularly true for clomipramine.
Hyperthermia, confusion, hyperflexia and myoclonus, which are indicative of serotonergic overactivity, may occur with this combination. Should such combined symptoms occur, the patient should be closely observed by a physician (if necessary hospitalised) and appropriate treatment given.
Moclobemide should not be co-administered with serotonin (5-HT) re-uptake inhibitors (including those which are tricyclic antidepressants, e.g. clomipramine). After stopping treatment with 5-HT re-uptake inhibitors a time period equal to 4 - 5 half-life of the agent or active metabolite should elapse between stopping therapy and starting therapy with moclobemide.
Also avoid taking in combination with SSRI antidepressants or tricyclic antidepressants.
Here is a post from the Australia/Asia/NZ/Middle East Drug Discussion Archive detailing what is IMHO a case of typical non-fatal serotonin syndrome effects related directly to the combination of Aurorix and MDMA: Aurorix & E....WARNING!!
Another post, more recently added to Health Q&A Forum details an experience of serotonin syndrome related directly to the combination of Aurorix and MDMA, and follows on to the longer term effects: Did serotonin syndrome permanently ruin my brain? - update
Continuing the discussion of contraindications:
This means that you shouldn't take Aurorix with DXM either, because doing so increases the risk of severe negative side-effects. DXM is also contraindicated with MAOIs because, once again, combining these drugs brings a massively increased risk of serotonin syndrome.Cases of severe central nervous system adverse reactions have been reported after co-administration of moclobemide and dextromethorphan [DXM - BT]. Since cough and cold medicines may contain dextromethorphan, they should not be taken without prior consultation with the physician, such that non-dextromethorphan-containing alternatives may be given.
Please note: Mixed overdoses with moclobemide (e.g. with other CNS-acting drugs) could be life-threatening. Therefore, patients should be hospitalised and closely monitored so that appropriate treatment may be given. Do not be afraid to call an ambulance and tell the paramedics exactly what the person has ingested.
If you choose to blatantly ignore the above advice, and take it upon yourself to experiment with combinations of MDMA and MAOI, please take absolute minimum doses (ie. less than half of a 300mg Aurorix, less than half of a MDMA pill), avoid redosing if you aren't satisfied with the effect, and have a SOBER friend present who is prepared to call an ambulance immediately you notice the slightest difficulty. Often MDMA pills seem to have a large 'safety margin' but this is effectively removed when taken in synergy with MAOIs, making the chance for causing yourself harm far greater.
BigTrancer
[Edit: Changed title to include the street term "perma-roll" (29-10-03). Evidently this potentially fatal combination is becoming more popular lately in Melbourne, this warning needs to be spread as much as we can. BT]
Fixed formatting
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