will this mean that after just one inoculation will this becomes true for the 12.5 ? . Also for how long if more than one inoculation are made ( like three or four ) are we talking for months? years? life?
Depends on the timing between dosing, but half life should not change. It would need to be given quite regularly though, probably every 1-3 months for it to be effective, and in general effects should cease 6 months after the last injection.
Also, given longer periods of time presumably (with diminishing returns) more people could react to the antibody and have it rendered useless, maybe even 1 in 4 or 5 individuals.
I would also like to make a point clear that ; what would stop a vigulante pharmacist from arranging this with the local health care infirmary?
Several things.
0. "Jick's Law": It's possible to go down the street and punch random people in the gut. But we don't generally see this behaviour. The reason? The vast majority of people aren't assholes that will cause harm to random people, indiscriminately. And those that do, get locked up or seriously injured.
1. This may not mean anything anymore at all, but, the Hippocratic Oath is kinda basically "do no harm". (Though there is also a bit about prohibiting abortions. It was after all ancient Greece at the time.)
2. That sort of radical action would either need to be documented and approved by some higher power, or you would need a seriously maniacal person to train for years and become a practicing pharmacist, to do this for... what reason? A hatred of drug users?
3. Chimeric monoclonal antibodies are not something someone can order off the shelf easily. Just plain monoclonal antibody manufacture requires the ability to isolate animal or human white blood cells, grow them and keep them alive, identify those that produce antibodies that bind your compound of interest, fusing them with myeloma (white blood cell cancer) cells to make them immortal, then cloned
en masse and the best clones selected for further growth, and finally the antibody is isolated and packaged.
Now,
chimeric antibodies mean that in addition to selecting antibody-producing cells, the DNA is modified (usually parts taken from two different species, human and mouse) to produce a more effective antibody, making it that much harder.
This whole process would require a pretty well equipped biochemistry lab, the trained staff to run it, a lot of permits and paperwork, and plenty of money and time.
For monoclonal antibodies used to treat medical disorders, the costs often exceed $150,000 per patient per year.
Thermo Fischer (large chemical vendor) sells 100 uL (i.e. 0.1 mL) of a monoclonal antibody binding some part of the spike protien of COVID, for the low low price of CAD$1000.
And custom synthesis of a chimeric monoclonal antibody would be even more expensive. Also, you would have a paper trail several inches thick - people aren't going to do it all sneaky like.
4. If any reasonable person caught wind of someone giving random unapproved drugs to patients, especially as a trusted pharmacist, you'd lose your job and probably be jailed. This is no different.
I don't really see why anyone would do this. The ethical calculus is this:
Reasons For: One person will use methamphetamine less, for a while.
Reasons Against: They will probably hate the effects. Whoever doing so would need a working knowledge of monoclonal antibodies, they couldn't just call a chemical company and say "make me ch-mAb7F9". It would require a tremendous investment of money. There would be a paper trail, and possibly video evidence of it being given. It is easy to prove if it was given through blood tests. Doing so would probably result in job loss and a long jail sentence. Whoever is enough of an asshole to do it once would do it multiple times, meaning discovery is guaranteed given enough patients and time.
Also, meth use does cause paranoia. Just sayin'.
Honestly, an equally mean and illegal, but much more detectable and achievable crime, would be giving high dose haloperidol decanoate (long acting Haldol). But it's still an asshole move.
This is kind of like why we don't see people being poisoned with VX nerve agent or radioactive isotopes or anthrax. It's way more work than just shooting you with a 9mm or smashing a brick on your head.
and also ; see'ing as though drugs are illegal how am i going to get a pharmacist to stand up in court and get tried for this ? its like me rolling up to a police station and saying " help me ive just commited a crime " !
Sorry, I'm from a more enlightened part of the world that would probably see meth use as more of a disability than something to be arrested on based solely upon admission.
You could always (politely) ask for records of the injections you were given, namely the brand name and dose of the flu shots.
