If you want to know about Per.Withdraws from doing sub to soon after taking opioids read this ... I have read a lot of bs on this but first hand I can tell you try and wait 12- 24 hr. If you can but I have iv subs five hours after doing opioids cuz I was un happy with my buzz you will get the PW fx but they will go away with in an hour and you will just fill the sub this is the gospel I have done it knowing I will get PWs but I knew they would go away and I would fill my sub . It is not for the faint of hart tho . I am tuff and it still sucks . But not as bad as not having a buzz lol .