Hey I am wondering If Trimebutine will provide an Opium high like oxycodone or hydrocodone, I did some research and found this:
"Differences of affinity to and selectivity for trimebutine between peripheral and central opioid receptors have been investigated. Trimebutine inhibited electrically induced contraction of guinea-pig ileum (GPI) and mouse vas deferens (MVD) but not of rabbit vas deferens, and the inhibition was antagonized by naloxone and, to lesser extent, by nor-binaltorphimine (nor-BNI). The pA2 values for morphine and trimebutine with naloxone were higher than the values for these compounds with nor-BNI in both GPI and MVD preparations. GPI preparations incubated with a high concentration of morphine or trimebutine developed tolerance; however, there was no cross-tolerance between them, suggesting difference in the underlying mechanisms. In mouse and guinea-pig brain homogenate trimebutine was about 1/13 as potent as morphine to displace the [3H]naloxone binding, while it has no appreciable affinity for kappa-opioid receptors in [3H]U-69593, a selective kappa-receptor agonist. These results suggest that trimebutine, showing its low affinity to opioid receptors, possesses mu-receptor selective properties rather than those of kappa-opioid receptor in the peripheral tissues and in the central brain homogenate."
I also found a thread of someone who said they got an opium high from this: http://www.bluelight.org/vb/threads/778781-Trimebutine-the-lost-opioid
I just wanna be safe and know if I can OD I have the 300mg pills I was planning on popping 2 and waiting to see what happens but I just wanna make sure I dont OD and there is so little info on this substance...
Also I have prescribed 20mg of fluoxetine daily for anxiety and I can find 0 info on if mixing these 2 is safe? Ive done oxy and hydro on prozac before an been safe..
"Differences of affinity to and selectivity for trimebutine between peripheral and central opioid receptors have been investigated. Trimebutine inhibited electrically induced contraction of guinea-pig ileum (GPI) and mouse vas deferens (MVD) but not of rabbit vas deferens, and the inhibition was antagonized by naloxone and, to lesser extent, by nor-binaltorphimine (nor-BNI). The pA2 values for morphine and trimebutine with naloxone were higher than the values for these compounds with nor-BNI in both GPI and MVD preparations. GPI preparations incubated with a high concentration of morphine or trimebutine developed tolerance; however, there was no cross-tolerance between them, suggesting difference in the underlying mechanisms. In mouse and guinea-pig brain homogenate trimebutine was about 1/13 as potent as morphine to displace the [3H]naloxone binding, while it has no appreciable affinity for kappa-opioid receptors in [3H]U-69593, a selective kappa-receptor agonist. These results suggest that trimebutine, showing its low affinity to opioid receptors, possesses mu-receptor selective properties rather than those of kappa-opioid receptor in the peripheral tissues and in the central brain homogenate."
I also found a thread of someone who said they got an opium high from this: http://www.bluelight.org/vb/threads/778781-Trimebutine-the-lost-opioid
I just wanna be safe and know if I can OD I have the 300mg pills I was planning on popping 2 and waiting to see what happens but I just wanna make sure I dont OD and there is so little info on this substance...
Also I have prescribed 20mg of fluoxetine daily for anxiety and I can find 0 info on if mixing these 2 is safe? Ive done oxy and hydro on prozac before an been safe..