I have taken tramadol a lot of times in doses from 100mg to 600mg and I know well its effects. Tramadol is mu opioid agonist but too is Inhibitor of the reuptake of serotonin and norepinephrine. This dual action produces a very important instantaneous high mood and the problems are see without suffer. Tramadol in a dose of 50-100mg three times a day is more effective for depression than all the antidepressants. I don't know why tramadol is not used to treat depression. Kill the depressive mood in 45 minutes after take it. I think that is not used as antidepressant because is pleasant and the actual medicine think that the wellbeing is a undesirable side effect instead of a pleasure for the patient that makes him disease less painful. I think tramadol is a real antidepressant that acts immediately and brings a state of positive mood and well-being instead the normal antidepressant which takes one month to act with very bad side effects and when acts brings a state of emotional death no feeling bad but neither well