Opioids Tramadol 50mg + Wellbutrin 300mg xl Worth it?

[Tangy4747]

If both are taken will it cause severe side effects? I understand the chance of seizures & serotonin syndrome, but will they counter each other? No opioid dependence btw. Time on Wellbutrin = 4-5 months. 1st time Tramadol.

 

[supersonic89]

I know bupropion is an inhibitor of the cyp2d6 enzyme, one of the same enzymes that tramadol uses to metabolize into odesthemyltramadol, so tramadol won't do shit for you, for analgesia or recreationally.

 

[modocmodoc]

No, don't.. as others said, both lower the seizure threshold

 

[DeathIndustrial88]

I know bupropion is an inhibitor of the cyp2d6 enzyme, one of the same enzymes that tramadol uses to metabolize into odesthemyltramadol, so tramadol won't do shit for you, for analgesia or recreationally.

Yes, I answered all of this for this person on the Tramadol thread. I guess my answers weren't good enough. lololol

Both absolutely lower the seizure threshold and Wellbutrin pretty much blocks most euphoric drugs from releasing any more dopamine, not to mention 50mg of tramadol is incredibly low dose, even for an opiate naive individual. So he won't feel shit.