Fornax55
Bluelighter
- Joined
- Jun 17, 2010
- Messages
- 466
How does this work? Couldn't find anything in the search. I know (or I'm currently under the impression) that receptor downregulation is a huge factor in the development of tolerance. Antagonists, with repeated use, tend to upregulate receptor density. So what mechanism is responsible for the development of tolerance to antagonistic substances, such as DXM or CBD?
Furthermore, are any antagonistic substances known to cause dependency and withdrawal?
Furthermore, are any antagonistic substances known to cause dependency and withdrawal?