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Lysergamides The Small & Handy RU-28306 Thread

Solipsis said:
NBOMe's have that relative selectivity for 2A vs 1A... they aren't the greatest but maybe less unsafe than some entirely novel structure?
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Don't phens in general usually lack any major affinity for 1A? The biggest challenge seems to be finding compounds that are selective for 2A over 2C.

25I-NBOH, a relatively easy-to-find compound, is actually among the most selective 5HT2A agonists known (yes, even more selective than the NBOMe's).

I think only 25CN-NBOH and Juncosamine are more selective, but the former is too short-lasting and the second too complex of a synth to be considered worthwhile by RC vendors.
 
Hodor said:
25I-NBOH, a relatively easy-to-find compound, is actually among the most selective 5HT2A agonists known (yes, even more selective than the NBOMe's).
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25I-NBOH isn't selective for 5-HT2A vs. 5-HT2C. According to the following study, 25I-NBOH binds to 5-HT2A and 5-HT2C with pKi values of 9.15 and 8.85, which is only a 2-fold difference in affinity (too low to be classified as an appreciable affinity difference).

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963123/
 
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Lol juncosamine. What a crazy ass name. If it sucks i guess thats why they named it junkosamine, well cuz its junk. Lls
 
A guy in nichols' team is called jose juncosa, so I guess that's why. ;)
 
I like the structure of this one but DMT is a bitch compound to get analogs that are truly analogs. Waiting for the reports, anyway
 
Drumroll please..... RU-28306. Pics of the visually elusive compound and trip reports

So I received a 200 mg sample of RU-28306 last night from the continent of Asia and I was surprised to see this purplish/gray chalky almost gas-like substance in the bag. It was literally impossible to photograph, as no lighting or angle would possibly actually pick anything up..... Weird. It's almost like it's as visually trippy on a macro level as it is on a micro level (remember the cute little alien toys in the machines on Toy Story? That's this molecule 2-d.....)


But the pics that don't accurately portray it's stunning visual display of elusiveness do show my carelessness when handling this new and potentially potent (PROBABLY POTENT IF EVEN ACTIVE) compound. LOLZ. Look at my sweaty palms holding it. I was vigorously flicking the baggy bare handed in order to try and get it to stay clumped close enough together to get a shot but to no avail. However, in the meantime, I was successful in absorbing a small dose strong enough to send me to a +1-+2 literally in less than 10 min within handling the stuff. I will be titrating up starting with 400 mics beginning this Saturday and will increase the dosage accordingly. I'll post details of the effects once I achieve their onset to a significant degree. I was thinking of levels along the lines of:
400 mics
1.2 mg
2.4 mg
4.8 mg
10 mg
25 mg
50 mg
100 mg

I doubt I'll have to reach the latter 2-4 dosage ranges but we shall see.


Now if I could only figure out how to post pics id show y'all what this here stuff looks like...
 
Whoa so it's active in the microgram range? Also how long did those effects last and is there anything byou cancompare it too?
 
Pics and trip report? Your title is a tad misleading, well a tad and all the rest! What reasoning are you using on you dosing?
 
I think he intends to add pictures and trip reports when he can. As a new member he probably isn't aware of other threads that would be a better place for this, although I would encourage him to use the search function and possibly lurk a bit more before continuing to post.

I for one have been interested in this compound for quite a while, and am excited to hear that someone has finally got a hold of it, although it would be wise not to get ahead of ourselves.

OP, it's good to hear that you're treating this little-known substance with caution. How are you measuring out such small doses? Volumetrically perhaps? I'd recommend to wait at least two weeks, preferably a month, between each dose to prevent tolerance from corrupting your data. Oh and by the way, welcome to the forum.
 
Bigazznugz said:
The melting point of this chemical is much higher than dmt. So i dont know for sure but vaporization might not be very effective.
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Melting point shouldn't be an issue so much as solubility seeing as most RC tryptamines are sold as a fumarate salt.
 
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Starless said:

Melting point shouldn't be an issue so much as solubility seeing as most RC tryptamines are sold as a fumarate salt.
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Seems to be available as the HCl salt. I think it's too early to say anything about wether it's possible to vaporize it or not. aMT is in it's structure, so it's probably resistent to MAOI, which means it's probably going to be orally active. Potency is probably going to be like it's binding: "closer to DMT than LSD", so maybe again like aMT, 25-50 mg. It's all just pointless speculation of cause. But it's unlikely it's going to be the next NBOMB. But we will see.

It's a very interesting compound for sure, and it could open up for a whole new line of "tryptamine"-ish psychedelics. But it's waaaay to expensive imo, and I don't think it's going to be special enough to warrant that. It's probably a Safe bet it's going to stay a novelty.
 
Incunabula said:
Seems to be available as the HCl salt. I think it's too early to say anything about wether it's possible to vaporize it or not. aMT is in it's structure, so it's probably resistent to MAOI, which means it's probably going to be orally active. Potency is probably going to be like it's binding: "closer to DMT than LSD", so maybe again like aMT, 25-50 mg. It's all just pointless speculation of cause. But it's unlikely it's going to be the next NBOMB. But we will see.

It's a very interesting compound for sure, and it could open up for a whole new line of "tryptamine"-ish psychedelics. But it's waaaay to expensive imo, and I don't think it's going to be special enough to warrant that. It's probably a Safe bet it's going to stay a novelty.
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I imagine the price is due to it being made to order as a custom synth, which is very expensive. If testing proves promising and public demand increases then larger pre-made batches could be justified, significantly lowering the price.
 
Centralized, but I am still quite skeptical about the activity of this substance and it's distribution seems to be quite limited, let's keep this clean and civil and try to only contribute if you have new information or ideas etc.
 
Yes, admittedly, as a new user I am naive as to how to post pics or when I should wait until posting. Between this site and reddit, there's just been a lot of intrigue surrounding this substance and I was anxious to get the word our there with these pics. I wish I knew how to post them. Tips anyone? I also wanted to let everyone know that the potency might be very high on this and them I'll update with trip reports as they occur. In the meantime I'm
anxious to show everybody what this shit looks like. It's weird.
 
Use tinypic or photobucket... you can upload photos for free and then it will give you the forum tag to insert it (you'd paste that in here), or you could use the direct link and press the insert image button in this little post typing area and paste in the direct link.
 








In the last pic, the bag on the left is the RU-28306. The stuff on the right is AMB-FUBINACA. For you pic porn freaks.
as for the effects felt off the absorbed dose the other night, I was feeling very psychedelically high like I had just eaten 2 grams of mushrooms but the effects were not too psilocybin-esque. It was a very euphoric high and I was definitely getting solid visuals on my hands. I'll post trip reports as they occur.
 
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This thread is meant to become something of a repository of information, please treat it that way - the images are getting truncated.

NSFW:






 
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Honestly, I don't think the powder looks that special. Maybe just a little impure, and in a much too big baggie.

Remember, live trip reports are frowned upon here (they make the thread hard to read) We are all looking forward to hear your experiences with RU. But when you've tried it, make a short write up of the effects here, and then post the real trip report to the trip reports subforum.

Personally I'm still doubtfull this is really as superpotent as you seem to think.
 
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