Hello all,
For everyone who has made the induction from a potent full agonist (heroin, dilaudid, opana, etc) to Bupe, you are all too aware that the first few days, esp day 1, can be an extremely unpleasant transition. I'm not referring to precipitated WD from dosing the bupe too soon, just the act of switching from a potent full agonist to the partial agonism that bupe offers can be pretty brutal.
With that in mind, I'm curious if anyone tries to cross Titrate the full agonist and bupe simultaneously to ease what can otherwise be a jarring transition.
For those that aren't familiar w what cross titration is, it would look something like this:
Say you have been maintaining on 8mg dilaudid IV around 6 times a day and you now want to switch to bupe. The idea I'm proposing is on the morning you decide to make the switch, you dose a small dose of bupe, maybe .25 to .5mg. Within 30mins to an hr you will likely begin to feel uncomfortable and hints to WD, at which point you dose a full 8mg IV dilaudid. Later that day you dose a bit more bupe, perhaps another .5mg, and some time after that another dose of dilaudid, and repeat this process that day.
The next day you dose a bit higher on the bupe and drop your dilaudid dose.
This process is repeated but by day 3 or 4 at the latest, you should be fully switched over to bupe and no longer taking the dilaudid or whatever is your full agonist of choice.
I want to be clear I am not suggesting anyone try this as I've not experienced myself, it just theoretically seems to me to be a way to ease that transition to make things more manageable.
What I would LOVE to hear is from anyone who has done something like thiis and what their experience was like relative to the usual bupe induction of simply waiting for WD to kick in and abruptly switching to bupe. Your cross titration doesn't have to be exactly like my example, but I'm just hoping to hear experiences from people who have tried this type of approach- slowly adding small doses of bupe will simultaneously dropping their dose of full agonist until you have fully converts to bupe.
I would think this would make for a smoother transition. The initial low doses of bupe shouldn't be enough for precip WD to be a concern. However it is possible that ppl who have tried this found it didn't make the transition any smoother and simply prolonged the unpleasant induction phase.
Surely people have tried this, so I'd really appreciate if you would share your experiences. Thanks.
For everyone who has made the induction from a potent full agonist (heroin, dilaudid, opana, etc) to Bupe, you are all too aware that the first few days, esp day 1, can be an extremely unpleasant transition. I'm not referring to precipitated WD from dosing the bupe too soon, just the act of switching from a potent full agonist to the partial agonism that bupe offers can be pretty brutal.
With that in mind, I'm curious if anyone tries to cross Titrate the full agonist and bupe simultaneously to ease what can otherwise be a jarring transition.
For those that aren't familiar w what cross titration is, it would look something like this:
Say you have been maintaining on 8mg dilaudid IV around 6 times a day and you now want to switch to bupe. The idea I'm proposing is on the morning you decide to make the switch, you dose a small dose of bupe, maybe .25 to .5mg. Within 30mins to an hr you will likely begin to feel uncomfortable and hints to WD, at which point you dose a full 8mg IV dilaudid. Later that day you dose a bit more bupe, perhaps another .5mg, and some time after that another dose of dilaudid, and repeat this process that day.
The next day you dose a bit higher on the bupe and drop your dilaudid dose.
This process is repeated but by day 3 or 4 at the latest, you should be fully switched over to bupe and no longer taking the dilaudid or whatever is your full agonist of choice.
I want to be clear I am not suggesting anyone try this as I've not experienced myself, it just theoretically seems to me to be a way to ease that transition to make things more manageable.
What I would LOVE to hear is from anyone who has done something like thiis and what their experience was like relative to the usual bupe induction of simply waiting for WD to kick in and abruptly switching to bupe. Your cross titration doesn't have to be exactly like my example, but I'm just hoping to hear experiences from people who have tried this type of approach- slowly adding small doses of bupe will simultaneously dropping their dose of full agonist until you have fully converts to bupe.
I would think this would make for a smoother transition. The initial low doses of bupe shouldn't be enough for precip WD to be a concern. However it is possible that ppl who have tried this found it didn't make the transition any smoother and simply prolonged the unpleasant induction phase.
Surely people have tried this, so I'd really appreciate if you would share your experiences. Thanks.
