Many years ago, I lost a friend to schizophrenia so using my education, I discovered that the cerebrospinal fluid of schizophrenics had EITHER an excess of DOPAC (dopamine metabolite) or a lack of NMDA. Today, ALL neuroleptics are based on the dopamine hypothesis. Refractive patients eventually end up with clozapine (a drug which increases morbidity, knocking an average of 10 years of the patients life). One of the effects of clozapine is to release D-serine (and agonist at the NMDA receptor) AND prevents the impaired expression of NMDA receptors.
Sarcosine was trialled on people suffering schizophrenia. This was a random sample of sufferers. It proved to have a positive impact in both negative and overall symptoms. I know LY-404,039 was trialled in Russia and proved to be statistically ineffective BUT, once again, no screening was carried out to see WHICH of the patients would have benefitted.
I don't think anyone has connected the dots before. Could it be that the people on the most hazardous neuroleptic are being totally ignored by Big Pharma because they can only expect it to benefit 10% of sufferers? This still adds up to millions of people BUT it seems that The NMDA Hypothesis is being actively ignored?
If you, or someone you know is on clozapine, please make them aware of these facts. For too long psychiatric patients have been talked down to with nobody listening to their voice.
If we can find a sufficient number of people prepared to hassle Lilly, the WORST neuroleptic could be removed from the shelves with safe, side-effect free medications that give their family back the WHOLE person.
Thank you for reading.
Sarcosine was trialled on people suffering schizophrenia. This was a random sample of sufferers. It proved to have a positive impact in both negative and overall symptoms. I know LY-404,039 was trialled in Russia and proved to be statistically ineffective BUT, once again, no screening was carried out to see WHICH of the patients would have benefitted.
I don't think anyone has connected the dots before. Could it be that the people on the most hazardous neuroleptic are being totally ignored by Big Pharma because they can only expect it to benefit 10% of sufferers? This still adds up to millions of people BUT it seems that The NMDA Hypothesis is being actively ignored?
If you, or someone you know is on clozapine, please make them aware of these facts. For too long psychiatric patients have been talked down to with nobody listening to their voice.
If we can find a sufficient number of people prepared to hassle Lilly, the WORST neuroleptic could be removed from the shelves with safe, side-effect free medications that give their family back the WHOLE person.
Thank you for reading.