Since I didn't find any other thread about it here, I'll divide my "experiments" with some facts
My history (just skip this part if you want the Bupropion technique)
1. I was diagnosed with ADHD by my neuropsychologist which I've been seeing for years after a battery of tests and days of conversation. She was the one who brought the ADHD topic, I always thought I had lack of attention because I'm anxious. I tried cocaine in several ways which I thought wouldn't be harmful and it worked (see my previous threads) and it was kinda working until I noticed a mild addiction was forming and decided to stop.
2. She wrote a report about my case and gave me to take to my psychiatrist. He is a douche and I knew he wouldn't even care anyway. He said he "disagrees" with my neuropsychologist (I didn't even bring the topic to him or to any psychiatrist before. He just "disagreed with her", even after several concentration tests were performed and were positive for ADHD and besides years of therapy with her.). He is also the first psychiatrist to say I'm too "aggressive" and that most my previously diagnosed anxiety episodes were actually manic episodes. I ended up agreeing with him, that I may have social anxiety and mania. He prescribed me quetiapine which was horrible and turned me into a zombie, as reported by my previous threads.
3. I was able to at least convince him to change my Pristiq to Wellbutrin to see if works. He did it.
So, about the Bupropion:
1. Actually, the only reason why this doesn't works exactly like an amphetamine is that it's extensively converted into other metabolites which don't target DA and NE o release dopamine and norepinephrine. Their concentration rapidly overcomes Bupropion's concentration in a MUCH higher level, like 80% more (source:
https://en.wikipedia.org/wiki/Bupropion#Pharmacology ).
2. Bupropion is metabolized by
CYP2B6, which, according to several sources, the strongest inhibitor of this enzyme is "orphenadrine" (it's even the one they warn about in their official
printed directions leaflet. I thought "cool, orphenadrine is fucking cheap and it's a muscle relaxer, something I very much appreciate". Turns out that, unfortunately, orphenadrine (according to this study
http://dmd.aspetjournals.org/content/32/6/626 ) didn't even touch bupropion metabolism in vitro.
The drug with the lowest IC50 was Ticlopidine. I found it. And found a study in humans after that (
https://www.ncbi.nlm.nih.gov/pubmed/15961986 ). Perfect. Ticlopidine indeed increased Bupropion AUC by 83%, so I'd be taking like, 83% "pure" bupropion using those doses in the article. This is indeed a very high increase. I'm actually kinda afraid of trying and having seizures since I'm also benzodiazepine dependent (but taking my normal dosages). Do you guys know about any OTC medicine that increases the seizure threshold?
My final questions, for you guys that understand about this much more than me:
Does it make sense? Am I'm gonna be able to turn Bupropion into a stimulant-like drug without doing stupid things like crushing it or snorting it?
Sorry for my English, I hope you guys are able to understand it.