Personally, I have yet to even try a 4-AcO compound (4-AcO-DMT is on the to-drop list.) I have had the greatest number of experiences with 4-HO compounds and they have had the largest impact on my life by far.
I've done DiPT before but my DMT attempts have been unsucessful. I found 5-MeO-MiPT to be a bit inconsistent (1 good experience and 1 mildly negative one) with an annoying body load. So based on my experiences with psilocybin (technically 4-PO, I know), 4-HO-MET, and 4-HO-MiPT, I'm going with the 4-subs.