One more question though, can you hole fairly easily on PCM? It seems like some people have difficulty reaching that state, but I found it fairly difficult to properly hole on MXE as well, though I was avoiding IM administration.
Hmm. Be
very very careful. I'm more and more thinking of the "hole" being something unique to ketamine because of the sum of its activities, probably in particular HCN1-blockade. The more selective dissociatives aren't physically imparing and this makes them
dangerous.
The MXE freakouts and all that might be due to people not realizing how high they already were because of the lack of immobilization etc. Pure NMDA antagonists can be
very lucid. Here it's a pure question of mind control whether you are interacting with the everydays reality or drifting away into dissoverse. Not unlike thinking and speaking, and I see it basically as a lucid dreaming state (where you can wake up or take control, but need to know you're dreaming for at first). There is no point where a hole begins or ends. Just as dissociation increases it becomes easier and easier to disconnect from reality, forget about sensory input and enter dreamlands. A dark room, comftable bed etc. facilitates this of course.
But now take a lingering unconscious psychosis, non-integrated traumatas or other memories (in fact my dissoverse often consists of what I've seen and experienced the last hours or days, and entering it is like falling asleep). Then things go haywire.
I get the impression that PCM might end up being just as batch dependent as MXE was towards the end of its availability, with all the different synths.
But I will warn you in advanced. I think it makes one stink. Like body odor.
I think it was the desclorketamine seeping out of my pores.
But this chem... I don't know, may make sweat stink.
I can assure you,
pure deschloroketamine has no smell and doesn't make you smell either and I'm not speaking about a single use but much of it over multiple days. It's the impurities, they also make up these batch-to-batch differencies and weird heavy negative side effects from heavy use,
including psychosis. Think of them being like huffing gas. No real psychoactive effects but plain intoxication in the sense of this word. I too couldn't have imagined how strong the effects of a fraction of synthesis leftovers can be (if we have something that is, say, 87.5% pure) but they are.
The same as we had with mephedrone (at least concerning the stinky sweat). Some of these things build up in your body and get excreted very slowly.
Just that when one uses chemicals for recreation, sometimes exactly these toxins make up for a subjectively better trip (more vivid or bizarre hallucinations, stronger hit etc). This is true too with heroine, seemingly.
Plain NMDA antagonism doesn't make the full hole experience, initially it causes an increased output of neurotransmitters like serotonin and dopamine but with longer acting antagonists the state becomes dull, boring and lonely - even depressive because of the lack of stimulation from dissociated sensory input. Part of full-on imaginations is probably choline antagonism which K, DXM, probably MXE etc. exhibit, and/or sigma agonism, 5-HT(2a) activity. Dopamine causes the effects we all know. And so on.
So - a boring dissociative is a more selective one, if you ask me. It could also make a better one, because with a very selective one in a perfect world you could mix and match the additional effects the way you like but because none of all these agents is truly selective and all have differing metabolisms and half lifes this becomes dangerous. So it's about finding a molecule with the best overall profile for a certain usage.
When expecting the effects of e.g. ketamine, or MXE from a more selective one, danger is that you'll dose higher or re-dose more than necessary and go past the level of NMDA antagonism you want for the desired effects.
--
Also, again, while I can't say anything correct or meaningful, I would bet that
pure O-PCM isn't any more of an antibiotic than ketamine. At the least it doesn't weaken my immune system, doesn't disturb digestion or exhibit other significant physical / mental negatives when used in low dose, mutiple times a day over 10 days for now (don't do this unless you're as despreate as I am, having tried countless medications and all with no success, and know what you're doing).
I developed a skin rash from sampling/titrating amfonelic acid just a few times before mental effects were achieved.
What O-PCM/PCE lack in comparision to MXE is SERT affinity. Venlafaxine makes a good combination. NMDA antagonism has a distinct warmth from (endorphin release? mu potentiation? whatever) by itself but without contributing factors one needs to dose higher to achieve a satisfying intensity, leading to a longer "come-down" (lingering NMDA antagonism) and other psychotomimetic side effects.
