psood0nym, you have experience with both acetoxy and hydroxy DPT, right? Which one do you consider best? And in which way did you find them to be different?
Yes, I have experience with them both. It's really hard to judge because, as I've written about in the 4-ho-DPT thread, the qualitative effects of the doses I'm most familiar with (35-50mg insufflated) are more temperamental and synesthetic in their focus than most psychedelics. Typically the oh versions of 4-sub tryptamines are qualitatively more turbulent and serious than their AcO counterparts (which are often thought of as "smoother" and more euphoric), and that's a side of them that's revealed most distinctly in their more cognitive effects. However, my IM 4-AcO-DPT experience was far more rough and tumble than any of my 4-ho-DPT experiences, but as stated, that could have to do with an unexpected potency increase relative to insufflation, combining it with MXE, or a large potency difference between syntheses (this last possibility strikes me as least likely).
Shulgin laments how difficult 4-ho-DPT is to make in TIHKAL. I'm not sure what the details are of how the currently available 4-AcO-DPT is synthesized but if I had to go with one I'd chose it because if I recall correctly from what others have stated the AcO versions are both easier to get right and they're more stable (esp. fumerates). In any case, most people go with ho versions when they're looking for a little more unwieldy sort of experience, but, assuming my last combo session is reflective of how 4-AcO-DPT is in isolation, if one were to IM it I doubt "tame" would come to their mind as a description.
Help?!?! said:
I told you! 40mgs IM of 4-HO-DPT was pretty easily one of the most potent experiences I've ever had.
Heh, yeah, I certainly expected that 4-ho/AcO-DPT might have a bite at higher doses, particularly when IMed, there was just a lot of factors at play here making it difficult to guess at the time exactly how much stronger the experience would be. I'm now wondering if an experience I had a few years ago, the most profound of my life, had more to do with 4-ho-DPT than I thought.
I ended up having what I believe was a left-hemisphere partial seizure well after I thought the effects of 4-ho-DPT were over (I'd never had a seizure before then, nor have I since). I kept getting psychedelic thoughts and CEVs while I was trying to go to sleep after a very long night. Over a few hours I took 4 mL 1,4 butanediol, diphenhydramine, and had a few mixed drinks trying to just pass out. But the 4-ho-DPT effects just would not be denied. So instead of going unconscious like that much of all those depressant drugs might have typically resulted in I had a highly symbolic seizure vision of my own conception while the right side of my body jerked around! The combination of all those things had me pretty convinced I'd accidentally killed myself, heh. I've got most of that report written but there's some essential connections to an 35g mimohuasca/40g P.Torch "overdose" the weekend before that have been extremely difficult to include in a way that I think will make sense to readers.
In any case, the next night after the 4-AcO-DPT experience described above I experienced some mild brain zaps while going to sleep. Dondante notes in post #61 that:
DPT is actually one of the most serotonergic psychedelics if you judge by SERT/5-HT2A binding ratio. According to the paper below, DPT binds to the serotonin transporter at a dose 10x lower than required for appreciable 5-HT2A affinity, which probably means the drug also functions as a serotonin reuptake inhibitor.
I'm wondering if 4-ho/AcO-DPT might also have relatively powerful SERT activity, and if that may have played a role in both the brain zap symptoms and the seizure in combination with 1,4 BDO years ago. I don't think 4-ho/AcO-DPT are physiologically dangerous, but if this suspicion is true it's worth considering when combining either with other drugs (such as MXE, which is an SRI).