I've been experimenting with what I believe is 2F-DCK. I say "what I believe is 2F-DCK" as the source I bought it from unfortunately was a little shady on the details. They advertised it as DCK and listed the dosage range for DCK from psychonaut wiki but then also had further conflicting advertising saying that the where the chlorine atom normally was on the molecule, it had been substituted with fluorine instead. After trying some initial doses intranasally it only seemed to last about 1hr and was similar in effects, duration and dosage to ketamine although probably a bit weaker and slightly different in effects. It was by no means active in the dosage ranges listed for DCK on psychonaut wiki and by no means had a duration of 3-6hrs as listed for DCK on that same site.
Okay so let’s assume the possibility that I have in fact 2F-DCK. I have some significant disso tolerance so I find I don't usually get much out of regular ketamine as I don't like shoving large amounts of powder up my nose. When I'm already on a more potent disso such as MXE, 3-MeO-PCE, O-PCE, ect then a line of regular ketamine works well and I enjoy it.
I was looking for a different ROA rather than intranasal to be able to hopefully dose high enough to get medium to full effects. After reading the posts here I thought I'd try oral. So here was my experience...
I took 100mg of the suspected 2F-DCK in a capsule swallowed on an empty stomach. The appearance of the compound looked clear/white and was in large crystalline rocks with no obvious smell so there is no red flags visually or by smell of really obvious impurities and when I'd previously snorted it on another day there wasn’t much discomfort up the nose and was similar in nasal irritation (or lack thereof) to other high purity dissos. I also took two magnesium citrate capsules at the same time. I didn't know if this might negatively affect the absorption of the suspected 2F-DCK but I did this anyway in the hopes that if there is any chance of some of the fluorine breaking off the 2F-DCK molecules in the low Ph environment of the stomach acid then hopefully any inorganic fluorine would bind to the magnesium in the similar way that calcium is used to bind to fluorine in fluorine or hydrofluoric acid poisoning scenarios.
So what was interesting is that I waited about 3 hours and there was either no psychoactive effects or barely any psychoactive effects besides keeping me awake. I did however seem to get gastrointestinal discomfort (GI bloating and pain) which interestingly enough is listed on the Wikipedia page for fluoride toxicity when ingested:
https://en.wikipedia.org/wiki/Fluoride_toxicity
I also had headaches and insomnia. Although insomnia is normal on the tail end of any disso for me so I took some benzos after about 3hrs to help sleep.
Now I'm not suggesting I know for any certainty that fluorine can break off from the 2F-DCK molecule. I'm only hypothesising. I realise that my understanding of biochemistry especially in the realm of pharmacokinetics and pharmacology is limited. I know that academic sources have been quoted before stating that generally the carbon-fluorine bond in organofluorine compounds is considered to be very strong and that for this reason a number of organofluorine pharmaceuticals are not considered to be sources of fluoride poisoning. I will however give some food for thought and that is that methoxyflurane (Penthrox AKA The Green Whistle) is believed to be very toxic to the liver and kidneys due to inorganic fluoride breaking off during metabolism. Hence why I believe it's not used any more for general anaesthesia and only in used in lower doses such as for immediate pain relief on the way to hospital.
https://en.wikipedia.org/wiki/Methoxyflurane
Having had thyroid disease (hypothyroid) years ago I'm pretty well researched in the area regarding iodine and fluoride. Specifically the medical theory that fluoride lowers thyroid function and hence why it was used as a thyroid lowering medication in Europe in the 50's or 60's according to an old Merck Index I read. So the morning after taking the suspected 100mg of 2F-DCK I took 50mg of iodine (8 drops of Lugol's Solution) in water after a big breakfast. I did this as according to Dr David Brownstien when he tested on himself he found that while taking iodine in the milligram amounts, he excreted toxic halogens such as fluoride and bromide. So he theorised that toxic halogens compete with iodine and uptake in the thyroid. He also theorised through his experiments and research that taking sufficient doses of iodine (in the milligram amounts) caused the body to dump unneeded toxic halogens such as fluoride and bromide. His work was based on his mentor the professor of endocrinology, Guy Abraham who based his experiments on the average Japanese diet which was 13mg of iodine daily (roughly 100x more than modern western countries recommend taking daily).
If anyone is interested I believe that 100mg of 2F-DCK contains about 8.6mg of fluorine (if I've done my stoichiometry calculations correctly) (19 ÷ 221 x 100 = 8.6). The Wikipedia page on fluoride toxicity lists the ingestion of fluoride causing gastrointestinal discomfort to be roughly around 12-19mg based on my body weight. So even if the all the fluoride was to break off the 2F-DCK it should be only containing 8.6mg which I realise is under the amount listed. I still think it's worth food for thought as if there is 8.6mg of potential fluoride taken on an empty stomach, I doubt this would be in any way healthy and would not be surprised if it would cause gastrointestinal discomfort and headaches due to fluoride toxicity and probably not be great for the liver, kidneys and thyroid.
I generally try to avoid all drugs containing fluorine or bromine (as well as drinking reverse osmosis water to filter out fluoride and using fluoride free toothpaste) just to be on the safe side and have done a number of 24hr iodine loading tests and thyroid ultrasounds over the years to check that my consumption of daily iodine is okay and my thyroid and iodine levels are looking good. It seems to have worked and I seem to no longer have thyroid disease (hypothyroid).