If you take tapentadol or tramadol with a tricyclic compound (amitriptyline), you may be at risk of developing a potentially life-threatening condition called serotonin syndrome and your risk of suicide may increase.
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Contact your doctor right away if you experience easy excitability, agitation, loss of coordination, fast heartbeat, sweating, muscle spasms or seizures, or if you have any thoughts of suicide.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.