You'd be surpised about the NAC. I sure as hell was. The NAC dose that I took was around 400mg, and I dosed the dissociative a day or 2 afterwards. It actually took about a week before the dissociative had any effect at all. I was extremely surprised. I hadn't been on the NAC for a long time. I maybe took it 1 or 2 days at a low dose. I do have a perma-dissociative tolerance, but I can still feel the effects of low doses. I was also using 3-MeO-PCP which I am very familiar with. I got almost no effect from a dose of about 15mg, which is definitely active for someone with my tolerance.