Pretty comprehensive guide here:
SUPPLEMENTS GUIDE | ‘Pre-rolling’ and ‘Post-Rolling’ for MDMA to enhance the experience and reduce negative effects
IMPORTANT SUPPLEMENTS THAT MAY REDUCE OR PREVENT NEUROTOXICITY
N-Acetyl-Cysteine (NAC)
NAC is involved in the synthesis of Glutathione by our bodies. Glutathione is the main antioxidant produced by the human body. Supplementing NAC will mean more Gultathione produced, which can protect us against oxidative stress and damage to the brain.
NAC may also be helpful for healing the neurotoxic damage associated with cocaine and amphetamine use, as well as improving several mental disorders. Can be purchased online or in health/vitamin shops.
~NAC brings the magic back~
Na-R-Alpha Lipoic Acid (Na-R-ALA)
Na-R-ALA is a potent antioxidant that can fight off excess free radicals, helping prevent oxidative stress and neurotoxicity. A 2001 study showed it prevented MDMA neurotoxicity in rats, even when body temperatures rose. Can be purchased online or in health food/body building shops.
Acetyl L-Carnitine (ALCAR)
Another potent antioxidant that synergises with R-ALA, has shown to prevent MDMA neurotoxicity in rats. Can be purchased online or in health food/body building shops.
Highly bioavailable Magnesium
An important one and something most of us are deficient in. Supplementing Magnesium will give your body the substance it needs to naturally protect i's neurons from killing themselves due to excitotoxicity. Magnesium can also reduce or prevent teeth grinding, jaw clenching, and muscle tension.
Some forms known to be really well absorbed by the body include, Magnesium L-Threonate, Magnesium Citrate and Magnesium Glycinate. Can be purchased online, in Pharmacies, or vitamin/supplement shops.
Vitamin C
A common antioxidant found in fresh fruit and juice, especially citric fruits. has shown to prevent MDMA neurotoxicity and liver toxicity in rats. Vitamin C from fresh fruit and juice is preferred as it's better absorbed by the body. The chewable 500mg tablets are also a good option and are easily available from pharmacies and supermarkets.
Vitamin C and other antioxidants are known as 'free radical scavengers'. This is because antioxidants can prevent oxidative stress in your body by hunting down and removing the excess free radicals before they can damage or destroy neurons.
Grape Seed Extract (vitamin E and flavonoids)
Grape seed extract contains vitamin E and flavonoids. Rats deficient in vitamin E were found to experience an increased severity of MDMA induced neurotoxicity. Vitamin E and flavonoids are also potent antioxidants that will fight off excess free radicals and prevent oxidative stress. Not to be confused with grapefruit seed extract. Can be purchased online, in pharmacies, or in health food/vitamin shops.
SUGGESTED SUPPLEMENTS
Green Tea Extract (ECGC)
Green tea extract contains EGCG, an antioxidant which fights free radicals. Can also reduce the difficulty of urinating which some people experience while on MDMA. Purchased online, in pharmacies or health food/vitamin shops.
5-HTP
DO NOT CONSUME 24 HOURS BEFORE OR AFTER MDMA INGESTION, AS MAY INCREASE CHANCES OF SERATONIN SYNDROME.
Your body creates serotonin through a two-step process. First, the amino acid Tryptophan, which we get in our diets, is converted into 5-HTP. 5-HTP is then used by your body to make serotonin.
MDMA use has can block the enzyme in the body that converts Tryptophan into 5-HTP. So, for a couple of weeks after use, a lot of the tryptophan you're consuming through your diet isn't turning into serotonin. Taking 5-HTP skips this first step and will help replenish your serotonin levels much more quickly.
Taking it with Green tea extract as EGCG will help to make sure it's your brain that's getting the serotonin, not your gut. You can purchase 5-HTP online, or in body building/health food stores.
Melatonin
Melatonin is produced naturally by your body in low light and helps regulate your sleep pattern. Taking melatonin can help you get to sleep after taking stimulants. It is also a potent antioxidant that will help prevent any lingering free radicals from inducing oxidative stress and doing more damage. Purchased online, or in pharmacies.
DOSING GUIDE
6-12 HOURS BEFORE dropping
- Magnesium Glycinate or similar - 100-200mg
- Grape seed extract - 100mg
1 HOUR BEFORE dropping
- Magnesium Glycinate or similar – 100-200mg
- Grape seed extract - 100mg
- Vitamin C - 500-1000mg
- Grapefruit juice - small glass (optional)
ALONG WITH MDMA INGESTION
- Na-R-ALA -100mg
- Acetyl-L-Carnitine - 500mg
- Water - 250ml
- Electrolytes - 250ml
WHILST ROLLING
- Na-R-ALA - 200mg (ever 2 hours of the roll)
- Grape seed extract – 100mg
- Acetyl-L-Carnitine - 500mg
- Magnesium Glycinate or similar – 100-200mg
- Green tea extract – 400mg
- Vitamin C - 500-1000mg
- Water - 250ml (an hour or 500ml an hour when dancing)
- Electrolytes - 250ml (every 1-2 hours)
POST-ROLL
- Magnesium Glycinate – 100mg - 200mg
- Na-R-ALA - 100mg
- Vitamin C – 500 - 100mg
- Acetyl L-Carnitine - 500mg
- Melatonin – 5-10mg before bed (using larger doses for its antioxidant effect.)
- Water - 250ml - 500ml
- Electrolytes - 250ml
3-7 DAYS FOLLOWING MDMA USE
- 5-HTP – 100mg before bed
- Green Tea Extract – 400mg with 5-HTP before bed
- N-AcetylCysteine (NAC) – 600-1000mg (optional)
It is possible to enjoy yourself without having to pay such a huge price. Ever heard of pre-rolling and post-rolling? This article mainly focuses on the ways that MDMA (aka ecstasy) can cause damage to you, and ways to help combat or prevent damage by using supplements.
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