I have jumped on and off of subutex for years, and I used to be on a low dose.. around 2-3mg a day for the longest time, but on that dose.. I kept doing dope, dilaudid, oxy, opana, anything that had a decent strength opioid wise, and was able to get past the sub, even at 2mg.. I still had to wait like, at least 8 hours before doing anything, except for really good dope, or the ever so rare opana I would come across once in a while... and for the other like oxy and dilaudid, I would usually have to wait the normal 8, maybe 10-12 hours.. as long as I could stand to wait I would wait basically, and around 8 hours after taking 2mg of sub, I would want to do something, because the sub had worn off by that time, almost entirely.. I mainly would and still do slam my subs, so the duration of action is greatly reduced, opposed to taking them sublingually... I just do sub that way for the 100% BA, and my needle addiction.. and I wish I stayed just plugging it, as it was nearly just as good an ROA, was totally harmless, and had very similar effects and a fast onset like IV, very similar feeling.. Never make the mistake of slamming subs for that ~100% BA, don't let the numbers fool you, plugging SUPPOSEDLY only has around a 54-60% BA, from what I have read, but I don't see how... it was truly every bit as effective as IV is, without having to deal with the unhealthy lifestyle of shooting pills.. Anyways.. back to how long subs block your opiates? It all depends on what opiate, the ROA you take the sub, sublingual is the longest lasting, and 24mg of sub, is outrageously high dosage! Why would your doc put you on such an insanely high amount, none of my sub docs, the 3 I have seen over the years, have ever even suggested a dose that high, and the highest I have taken daily prescribed is 8-10mg a day... which is my current dose.. I like to do 2mg shots, throughout my day these days and don't do full agonists like dope or oxy anymore at all.. but the last time I did this, like I said, I waited 8 hours more or less, and then shot around 8-24mg of dilaudid usually just did 8-12mg shots at a time, then did more later.. or if not dilaudid, like 120-150mg of oxy which I didn't really shoot like I did with dillys or dope I preferred sniffing, plugging, and then smoking some oxy or maybe sniffing/plugging then shooting a little, not a big fan of IV oxy its over rated, or 0.3-0.5G of dope, usually did like 2 or 3 0.25G shots of dope when I did it.. and it always seemed to breakthrough, oxy being the least effective at getting past the bupe.. but dilaudid, opana, and dope, I had no problem after waiting 8 hours or so..