Wait 24-36 hours after last opiate intake till u take a sub. Subs are for recovery and abstinence and are not meant to get you high, unless your only coming off a couple of vicodin a day type habit u will feel a buzz from them, but if you are abusing heroin daily or taking 100s of milligrams of oxy or morphine suboxone will not get you high, even if u iv a whole box of strips.