First off I’ve read this forum for years but this is my first time posting so I hope I do it correctly.
My question is regarding the ceiling dose of Suboxone and how that relates to bioavailability. For instance I’ve heard that Buprenorphine can act as a full agonist in doses 2mg and under and Bupe as a whole has a ceiling effect at 32mg.
Are those ceilings only if you are taking the drug IV and thus getting 100% bio.?
I’ve read that Suboxone sublingual is anywhere from 10-30% bioavailability. For easy math let’s say it’s 10%. Does that mean that the ceiling dose is 320mg and 20mg for the norbupe to cause full agonist effects?
What bioavailability do these ‘ceiling doses’ go off of or how does the bioavailability relate to ceiling doses?
My question is regarding the ceiling dose of Suboxone and how that relates to bioavailability. For instance I’ve heard that Buprenorphine can act as a full agonist in doses 2mg and under and Bupe as a whole has a ceiling effect at 32mg.
Are those ceilings only if you are taking the drug IV and thus getting 100% bio.?
I’ve read that Suboxone sublingual is anywhere from 10-30% bioavailability. For easy math let’s say it’s 10%. Does that mean that the ceiling dose is 320mg and 20mg for the norbupe to cause full agonist effects?
What bioavailability do these ‘ceiling doses’ go off of or how does the bioavailability relate to ceiling doses?