I've experienced this as well.
It is my belief that DRI drugs block dopamine release from other drugs in different parts of the brain.
DRI stimulants work differently than dopamine releasing agents like amphetamine.
If I take welbutrin & then take suboxone, I don't get the mood-lift & energizing effect from the suboxone. Buprenorphine does weakly release dopamine similar to other opioids. So I believe by blocking the re-uptake of dopamine with welbutrin, you're also blocking dopamine release from other drugs. This is just a theory though as I don't have the science to prove it.
The same thing happens when I try to mix suboxone and ritalin as well.
I disagree with the take that it's because suboxone is a depressant & wellbutrin is a stimulant. First of all, if you're taking welbutrin orally, very very little of it gets converted into an active DRI. Plus this isn't a problem when suboxone is taken with other dopamine
RELEASERS. I find amphetamine & methamphetamine to potentiate the effects of suboxone. Actually opioids
are in fact potentiated by dopamine releasing stimulants.
They even use to make pills that were stimulant/opioid combinations waaaay back in the day because of this. It has absolutely nothing to do with mixing downers & uppers or any of that.
So yes, taking dopamine reuptake inhibitors does something that blocks the euphoria or mood lift from opioids (and various drugs) in my experience. But the opposite is true when mixed with dopamine releasers (like amphetamine/meth).