Yes. It’s not uncommon to have to try a number of pharmaceuticals / SSRI’s etc etc under medical supervision before finding the one that works. It took me a few years to settle on the combination that really works. Pharmaceuticals ultimately work better than any street drugs for long term mental wellbeing. That’s not to suggest that they don’t have undesireable side effects and that there is a fair bit of trial and error in finding the right one / combination for each individual.