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Some Interesting 2C-T Analogues (Chemical Masturbation)

2C-F's amphetamine equivalent is DOF, not DOEF. DOF is much, much less potent just like 2C-F. DOEF is similar to DOB in the size of the substituent and the electronegativity ... I wonder if they are comparable in effects. DOMF would surely be potent. It's similar to DOC in size and I'd wager in potency as well.
 
DOTFM is effective around 1-3mg, DOFM I would guess would be about 2x-3x that.
 
Dondante said:
2C-F's amphetamine equivalent is DOF, not DOEF. DOF is much, much less potent just like 2C-F. DOEF is similar to DOB in the size of the substituent and the electronegativity ... I wonder if they are comparable in effects. DOMF would surely be potent. It's similar to DOC in size and I'd wager in potency as well.
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I'm still confused, 4-fluoro's are useless because of their polarity, so why is 4-methylfluoro or 4-ethylfluoro any different? I didn't think the receptors would be that specific as to where the fluorine carbon is.

How do 4-ethyl-2,5-dimethoxy-PEA/Amphetamines compare to 4-ethylfluoro-2,5-dimethoxy-PEA/amphetamines? How does adding a fluorine to the end of the ethyl chain make the ethyl chain any more hydrophobic?
 
DOF is much, much less potent just like 2C-F
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I thought 2C-F was written off as inactive; DOF would be active I'd imagine because the alpha-methyl group will protect it from metabolic degredation, but whether it was a true psychedelic or just more like 2,5-dimethoxyamphetamine is something I don't have the faintest idea about
 
I didn't realize it was hydrophobic/hydrophilic. I thought it was electron withdrawing/donating that made the difference. I've tried DON and it was pretty damned good. 2CN is just OK. The physical SIZE of the thing at the 4 position seems to have a big impact. 4 fluoro amphetamine is fine, almost like amphetamine but slightly warmer, but you can't base a trippy drug on it. I do wonder about 2,4,5 triethyl amphetamine. Anyone got an opinion or better still experience...
Well here's a general preparation link
 
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bigmac74 said:
I'm still confused, 4-fluoro's are useless because of their polarity, so why is 4-methylfluoro or 4-ethylfluoro any different? I didn't think the receptors would be that specific as to where the fluorine carbon is.
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Well you got em backwards. No such thing as methylfluoro. But there is fluoromethyl, fluoroethyl, etc. One has to think of them as entire groups....i.e as a whole...not as ethyl + fluoro. The fluoroethyl and pentafluorethyl groups very much resemble the halogens (bromine, chlorine) and activity is very similar. A fluoroethyl is one group, not just ethyl with something 'seperate' on the end. Does that make sense?

haribo1..you tried 2C-N as well? I'd love to hear more....I only tried it once (a disaster) and did share a dose with a friend who found it a waste of time. But I'd love to hear your take as no other reports seem to exist.
 
^ The degree to which the 4-group is hydrophobic/lipophillic is one of the factors effecting binding affinity. That's why a more hydrophillic group like -NO2 (in DON) produces a lower potency drug. It doesn't matter if you have the most effective electron withdrawing group known in the 4 position, if it's not sufficiently hydrophobic it's not going to get a chance to interact
 
f&b,

your above answer has completely neglected to mention atomic size, not to mention functional group size. you know, steric issues.
 
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