So what's the deal with grapefruit juice?

[badrobot114]

Hi everyone,

It's my understanding that grapefruit juice inhibits CYP3A4 and thus should, in theory, prolong a roll and lower neurotoxicity. However, i've also heard people claim it can lead to dangerously high plasma concentrations.

Does anyone have conclusive information on this matter? does it truly inhibit CYP3A4 and is it safe to use for that purpose?

 

[matt2012]

don't know much about the pharmacology involved but as for intensifying the roll, in practice id does not produce the results that most people are looking for. you can have a look around here and some say it works and others say there is no difference. never tried it but without a general consensous, I just normally chalk it up as ineffective.