its simply not true that tramadol has no effect if not taken orally. it would just still take some time to get metabolized. injection ampules for tramadol do exist for a reason. im not saying at all that snorting is a wise thing to do but your reasoning is WRONG.
Tramadol has a minute affinity for mu-opioid receptors on its own, it does however still cause serotonin release and noradrenaline reuptake inhibition which contribute to a certain degree of its pain relieving and recreational effects - But it's the M1 metabolite (o-desmethyltramadol) that causes the main therapeutic effects of tramadol
(200x greater affinity for mu receptor than tramadol itself) and taking it orally is the best way to attain this. Very high BA and fast metabolism!
I know that there are tramadol ampoules and I have injected it myself for pain relief and it was practically inefficacious - all it does it gives you a quick serotonin boost and inhibits noradrenaline reuptake, which does reduce the perception of pain
slightly, however, opioid affects are practically absent when tramadol is taken via any other route than as it bypasses or at least delays first-pass metabolism, losing out on the majority of O-DMT. Like I said before, you wouldn't snort codeine - well this is exactly the same principle.
Tramadol has an oral bioavailability of ~75% which increases exponentially with repeated dosing (i.e. 50mg every half hour for 4 hours) up to near 90%! So what on earth would the point in snorting or injecting it when you delay and reduce the metabolism to o-desmethyltramadol to practically insignificant levels, potentially damage your mucus membranes when it would be more effective orally.
So actually, sHR00m, my reasoning is correct. Subjective as the
effects of tramadol may be, taking it orally is objectively the most clinically effective way of administering tramadol and I would stake my cock and balls on it being the most effective way of using recreationally as well.
