superbabydoc
Bluelighter
- Joined
- Jan 3, 2001
- Messages
- 4,411
I ripped this from Micromedex Poisindex - can't give you the link as it is password protected. (Edited+++ )
CAFFEINE
7.0 RANGE OF TOXICITY
A. Death following caffeine overdose is rare. Spontaneous emesis often serves to limit the amount of caffeine available for absorption.
B. Lethal dose in an adult is estimated to be 5 to 10 grams. However, as little as 1 gram will produce confusion, tremors, tachycardia, fever, vomiting and diarrhea. An adult survived a 22-gram overdose after cardiac resuscitation and charcoal hemoperfusion.
7.3 MINIMUM LETHAL EXPOSURE
A. ADULT
1. A single 1 gram dose of caffeine may cause confusion, tremors, tachycardia, pyrexia, vomiting and diarrhea; whereas a lethal dose in an adult is estimated to range between 150 to 200 milligrams/kilogram (Peters, 1967). Death was reported after 6.5 grams in an adult (Alstott et al, 1973) and 18 grams in a 19-year-old woman (McGee, 1980).
8.1 ABSORPTION
1. Absorption occurs more rapidly after oral (30 to 60 minutes) ingestion than after intramuscular administration.
2. A specific dose of caffeine is more toxic when administered intravenously than when it is given orally.
Dunno if this is much help, as you won't be able to reference it, but you may be able to find some of the articles quoted if you have access to a good library. If you want the rest of the page (there is heaps more) email me.
[ 22 January 2002: Message edited by: babydoc_vic ]
CAFFEINE
7.0 RANGE OF TOXICITY
A. Death following caffeine overdose is rare. Spontaneous emesis often serves to limit the amount of caffeine available for absorption.
B. Lethal dose in an adult is estimated to be 5 to 10 grams. However, as little as 1 gram will produce confusion, tremors, tachycardia, fever, vomiting and diarrhea. An adult survived a 22-gram overdose after cardiac resuscitation and charcoal hemoperfusion.
7.3 MINIMUM LETHAL EXPOSURE
A. ADULT
1. A single 1 gram dose of caffeine may cause confusion, tremors, tachycardia, pyrexia, vomiting and diarrhea; whereas a lethal dose in an adult is estimated to range between 150 to 200 milligrams/kilogram (Peters, 1967). Death was reported after 6.5 grams in an adult (Alstott et al, 1973) and 18 grams in a 19-year-old woman (McGee, 1980).
8.1 ABSORPTION
1. Absorption occurs more rapidly after oral (30 to 60 minutes) ingestion than after intramuscular administration.
2. A specific dose of caffeine is more toxic when administered intravenously than when it is given orally.
Dunno if this is much help, as you won't be able to reference it, but you may be able to find some of the articles quoted if you have access to a good library. If you want the rest of the page (there is heaps more) email me.
[ 22 January 2002: Message edited by: babydoc_vic ]