Sida cordifolia - ingredients and uses.

[izo]

next plant profile, nothing really unknown and only thing i knew was that it contains ephedrine:

Sida cordifolia - Wikipedia

en.wikipedia.org

has an anti-inflammatory and antipyretic effect, but in excessive doses it can cause hallucinations and miscarriages.

the following molecules have been found in different parts of the plant:

Phenethylamine - Wikipedia

en.wikipedia.org

Pseudoephedrine - Wikipedia

en.wikipedia.org

Ephedrine - Wikipedia

en.wikipedia.org

Vasicinone - Wikipedia

en.wikipedia.org

Choline - Wikipedia

en.wikipedia.org

Betaine - Wikipedia

en.wikipedia.org

beta-Sitosterol - Wikipedia

en.wikipedia.org

Stigmasterol - Wikipedia

en.wikipedia.org

Sterculic acid - Wikipedia

en.wikipedia.org

Malvalic acid - Wikipedia

en.wikipedia.org

Coronaric acid - Wikipedia

en.wikipedia.org

 

[izo]

1999 - Analgesic, antiinflammatory and hypoglycaemic activities of Sida cordifolia

Sida cordifolia extracts of the aerial and root parts showed good analgesic, antiinflammatory and hypoglycaemic
activities. The ethyl acetate (EA) extract of root (SCR-E) showed comparable antiinflammatory
activity with indomethacin and possessed significantly higher activity when compared with that of
the methanol extract of the root part (SCR-M). The ethyl acetate extract of both root and aerial parts of
Sida cordifolia (SCR-E and SCA-E) showed very good central and peripheral analgesic activities at a
dose of 600 mg/kg. The methanol extract of root (SCR-M) was found to possess significant hypoglycaemic
activity.

 

[izo]

2000 - Anti-inflammatory, analgesic activity and acute toxicity of Sida cordifolia L. (Malva-branca)

Sida cordifolia L. (Malvaceae) is used in folk medicine for the treatment of inflammation of the oral mucosa,
blenorrhea, asthmatic bronchitis and nasal congestion. The anti-inflammatory, analgesic effects and acute toxicity of
an aqueous extract of S. cordifolia were evaluated in animal models. The extract was prepared using leaves collected
before the flowering period. The aqueous extract (AE) showed a significant inhibition of carrageenin-induced rat paw
edema at a dose of 400 mg:kg administered orally, but did not block the edema induced by arachidonic acid. The AE
also increased the latency period for mice in the hot plate test, and inhibited the number of writhes produced by acetic
acid at the oral dose of 400 mg:kg. The aqueous extract of S. cordifolia showed low acute toxicity in mice.

 

[izo]

2005 - CNS pharmacological effects of the hydroalcoholic extract of Sida cordifolia L. leaves

Abstract
Sida cordifolia L. (Malvaceae), known as “malva branca”, is a plant used in the popular medicine for the treatment stomatits, of asthma and
nasal congestion. This work researched the acute toxicity of Sida cordifolia and its action on the central nervous system (CNS) because no
data in the literature have been found about of pharmacological activity of this plant in the CNS. The hydroalcoholic extract of Sida cordifolia
leaves (HESc) was used and the psychopharmacology approach began with the determination of LD50, where a low toxicity was observed in
mice. Depressive activity on CNS was demonstrated by several alterations in mice’s behavior in the pharmacological screening. In the motility
test, the HESc showed significant reduction of spontaneous activity at a dose of 1000 mg/kg (i.p.) at 30 and 60 min. The same form the HESc
also decreased the ambulation and rearing in open-field test at 30, 60 and 120 min at a dose of 1000 mg/kg (i.p.).

 

[izo]

2006 - Cardiovascular effects of Sida cordifolia leaves extract in rats

Abstract
The cardiovascular activity of the aqueous fraction of the hydroalcoholic extract of Sida
cordifolia leaves (AFSC) was evaluated. In normotensive non-anaesthetized rats was observed that
AFSC (5, 10, 20, 30 and 40 mg/kg, i.v.) induced hypotension (6F2%; 8F2%; 11F2%; 19F3%
and 33F3%, respectively) and bradycardia (0.3F3%; 13F4%; 38F6%; 64F7% and 80F5%,
respectively). Hypotensive response was completely abolished after atropine (2 mg/kg; i.v.) but
potentialized after hexamethonium (20 mg/kg; i.v.) (12F2%; 21F5%; 28F3%; 32F2% and
32F3%, respectively), while bradycardic response was completely abolished after atropine (2 mg/
kg; i.v.) and attenuated with hexamethonium (20 mg/kg; i.v.) (1F0.3%; 5F1%; 7F1%; 7F1%
and 10F1%, respectively). In hexamethonium treated rats, l-NAME significantly attenuated the
hypotensive response (9F2%; 14F1%; 16F1%; 16F2% and 22F3%, respectively). In
normotensive anaesthetized and vagotomized rats, hypotensive and bradycardic responses were
significantly attenuated (0.5F0.2%; 1F0.4%; 3F0.6%; 4F0.8% and 6F1%, respectively, n =6,
and 7F2%; 12F5%; 15F2%, 17F2% and 25F3%, respectively). The anaesthesia with sodium
thiopental did not affect the AFSC-induced responses when compared with those induced in nonanaesthetized
rats (data not showed). In conclusion, the results obtained so far show that AFSC
produce hypotension and bradycardia, mainly due to a direct stimulation of the endothelial vascular
muscarinic receptor and indirect cardiac muscarinic activation, respectively.

 

[izo]

2009 - Antistress, Adoptogenic Activity of Sida cordifolia Roots in Mice

Ethanol extract of roots of Sida cordifolia was evaluated for antistress, adaptogenic activity using cold restraint stress
and swim endurance in mice. Mice pretreated with extract of Sida cordifolia showed significant improvement in
the swim duration and reduced the elevated WBC, blood glucose and plasma cortisone.

 

[izo]

2011 - Sida cordifolia leaf extract reduces the orofacial nociceptive response in mice

In this study, we describe the antinociceptive activity of the ethanol extract (EE), chloroform (CF) and methanol
(MF) fractions obtained from Sida cordifolia, popularly known in Brazil as “malva branca” or “malva branca
sedosa”. Leaves of S. cordifolia were used to produce the crude ethanol extract and after CF and MF.
Experiments were conducted on Swiss mice using the glutamate and formalin-induced orofacial nociception.
In the formalin test, all doses of EE, CF and MF significantly reduced the orofacial nociception in the first
(p < 0.001) and second phase (p < 0.001), which was also naloxone-sensitive. In the glutamate-induced
nociception test, only CF and MF significantly reduced the orofacial nociceptive behavior with inhibition
percentage values of 48.1% (100 mg/kg, CF), 56.1% (200 mg/kg, CF), 66.4% (400 mg/kg, CF), 48.2 (200 mg/kg,
MF) and 60.1 (400 mg/kg, MF). Furthermore, treatment of the animals with EE, CF and MF was not able to
promote motor activity changes. These data demonstrate that S. cordifolia has a pronounced antinociceptive
activity on orofacial nociception. However, pharmacological and chemical studies are necessary in order to
characterize the responsible mechanisms for this antinociceptive action and also to identify other bioactive
compounds present in S. cordifolia.

 

[izo]

2012 - Toxicity assessment and analgesic activity investigation of aqueous acetone extracts of Sida acuta Burn f . and Sida cordifolia L. (Malvaceae), medicinal plants of Burkina Faso

Abstract
Background: Sida acuta Burn f. and Sida cordifolia L. (Malvaceae) are traditionally used in Burkina Faso to treat
several ailments, mainly pains, including abdominal infections and associated diseases. Despite the extensive
use of these plants in traditional health care, literature provides little information regarding their toxicity and the
pharmacology. This work was therefore designed to investigate the toxicological effects of aqueous acetone
extracts of Sida acuta Burn f. and Sida cordifolia L. Furthermore, their analgesic capacity was assessed, in order
to assess the efficiency of the traditional use of these two medicinal plants from Burkina Faso.
Method: For acute toxicity test, mice were injected different doses of each extract by intraperitoneal route and the
LD50 values were determined. For the subchronic toxicity evaluation, Wistar albinos rats were treated by gavage
during 28 days at different doses of aqueous acetone extracts and then haematological and biochemical
parameters were determined. The analgesic effect was evaluated in mice by the acetic-acid writhing test and by
the formalin test.
Results: For the acute toxicity test, the LD50 values of 3.2 g/kg and 3.4 g/kg respectively for S. acuta Burn f. and
S. cordifolia L. were obtained. Concerning the haematological and biochemical parameters, data varied widely
(increase or decrease) according to dose of extracts and weight of rats and did not show clinical correlations.
The extracts have produced significant analgesic effects by the acetic acid writhing test and by the hot plate
method (p <0.05) and a dose-dependent inhibition was observed.
Conclusion: The overall results of this study may justify the traditional uses of S. acuta and S. cordifolia.

 

[izo]

2010 - Antiperoxidative and antiinflammatory effect of Sida cordifolia Linn. on quinolinic acid induced neurotoxicity

Abstract Sida cordifolia is a plant belonging to the
Malvaceae family used in many ayurvedic preparations.
This study aimed at assessing the effects of ethanolic
extract of Sida cordifolia root on quinolinic acid (QUIN)
induced neurotoxicity and to compare its effect with the
standard drug deprenyl in rat brain. Rats were divided into
six groups: (1) control group (2) QUIN (55 lg/100 g bwt/
day) (3) 50% ethanolic plant extract treated group (50 mg/
100 g bwt/day) (4) Deprenyl (100 lg/100 g bwt/day) (5)
QUIN (55 lg/100 g bwt/day) ? 50% ethanolic plant extract
treated group (50 mg/100 g bwt/day) (6) QUIN (55 lg/
100 g bwt/day) ? Deprenyl (100 lg/100 g bwt/day). At
the end of the experimental period a status of lipid peroxidation
products, protein peroxidation product, activities
of the scavenging enzymes and the activities of the
inflammatory markers were analyzed. Results revealed that
the lipid peroxidation products decreased and the activities
of the scavenging enzymes increased significantly in the
brain of the plant extract treated group, deprenyl treated
group and also in the coadminstered groups. The activities
of markers of inflammatory responses such as cyclooxygenase
and lipoxygenase were found to be significantly
increased in the QUIN treated rats and this was decreased
upon the administration of plant extract and deprenyl. In
short, the study revealed that 50% ethanolic extract of Sida
cordifolia has got potent antioxidant and antiinflammatory
activity and the activity is comparable with the standard
drug deprenyl.

 

[izo]

paper roll:

1999 - Analgesic, antiinflammatory and hypoglycaemic activities of Sida cordifolia.pdf
2000 - Anti-inflammatory, analgesic activity and acute toxicity of Sida cordifolia L. (Malva-branca).pdf
2005 - CNS pharmacological effects of the hydroalcoholic extract of Sida cordifolia L. leaves.pdf
2006 - Cardiovascular effects of Sida cordifolia leaves extract in rats.pdf
2009 - Antistress, Adoptogenic Activity of Sida cordifolia Roots in Mice.pdf
2010 - Antiperoxidative and antiinflammatory effect of Sida cordifolia Linn. on quinolinic acid induced neurotoxicity.pdf
2011 - Sida cordifolia leaf extract reduces the orofacial nociceptive response in mice.pdf
2012 - Toxicity assessment and analgesic activity investigation of aqueous acetone extracts of Sida acuta Burn f . and Sida cordifolia L. (Malvaceae), medicinal plants of Burkina Faso.pdf
2013 - Wound healing activity of Sida cordifolia Linn. in rats.pdf
2014 - Phytopharmacological evaluation of ethanol extract of Sida cordifolia L. roots.pdf

 

[Neuroborean]

next plant profile, nothing really unknown and only thing i knew was that it contains ephedrine:

Sida cordifolia - Wikipedia

en.wikipedia.org

the following molecules have been found in different parts of the plant:

Phenethylamine - Wikipedia

en.wikipedia.org

Pseudoephedrine - Wikipedia

en.wikipedia.org

Ephedrine - Wikipedia

en.wikipedia.org

Vasicinone - Wikipedia

en.wikipedia.org

Choline - Wikipedia

en.wikipedia.org

Betaine - Wikipedia

en.wikipedia.org

beta-Sitosterol - Wikipedia

en.wikipedia.org

Stigmasterol - Wikipedia

en.wikipedia.org

Sterculic acid - Wikipedia

en.wikipedia.org

Malvalic acid - Wikipedia

en.wikipedia.org

Coronaric acid - Wikipedia

en.wikipedia.org

this plant is fairly interesting,
I wonder if it's possible to isolate compounds by group, for example the phenethylamines all together and the plant steroids in another part...
I just put some seeds on soil/earth today, so let's see if it works...
I read somewhere that the most interesting part of the plant is the ROOTS and you need to wait at least 7-8 months till the alkaloids are in the maximum (phytoepigenetic) expression.
I'll do some photos with explanations and all that

It seems that extracting the plant (a full spectrum maybe) it's the way to go, since the amount of ephedrine and pseudo is quite low, so one would need to use +10grams per dose to get a threshold/mild dose...

Has anyone any experience with it?

 

[izo]

Has anyone any experience with it?

i have 100x whole plant extract here, will report back.