Another day, in pain.
Same feeling. Feels like my shoulder muscles, back muscles, arm muscles & leg muscles are constantly aching. Similar to what I use to feel like after a good work out, except I don't even work out anymore (unfortunately, cause I'd love to).
I take my suboxone & get very mild, almost imperceptible relief. But I'm constantly drowsy & it wears off pretty fast, for a drug that's gonna be bound to my receptor for the next 48+hrs. I get about 2hrs of mild pain relief & then it wears off & i'm left with lethargy & slowed intestines & that's about all.
This also contribute to chronic, slowed down GI tract & muscle contractions.
Now obviously full agonists & short acting ones cause this too, but usually they're worn off enough the next morning that your intestinal contractions go back to somewhat normal, since you're in a mild or full blown withdrawal.
With suboxone however, I'm noting that after 5 years of daily use that my stomach just is fucked by it.
Starting to wonder that I might even have pelvic floor dysfunction now, cause I'm constantly peeing, can't get through the night without waking up to pee. And not only is my stomach constantly slowed down but lately it's been feeling like my muscles "down there" don't even contract like a normal persons would anymore & being able to just go to the bathroom & feel like I've really cleared out my system has become a daily chore, which I ironically didn't have to do during a decade of tramadol & heroin use.
It's impossible to "go without" your sub dose for a bit either to resolve the problem, because you'll be feeling shitty & craving long before it's fully even detached from your receptors.
I'm almost at a point where I'm ready to ditch suboxone because of this very reason, among a slew of others. But I'm afraid to because I don't think I could make it without some kind of opioid. Kratom isn't gonna cut it for me. I think it's bullshit that I couldn't switch to something like tramadol or a different shorter/medium acting opioid.
I honestly don't know what do anymore. And obviously having to live such a way would induce depression & mental illness onto a person. But I'm pretty sure it's designed to do just exactly that. "Gee Deathindustrial, we really need to take care of that depression of yours, let's try countless other drugs that that have never worked & have even caused you more harm than opiates themselves & let's just ignore the real causes of your daily suffering".
@plumbus-nine I've definitely been keeping up with your plight & reading what you've said. It resonates with me incredibly. And although we both might be after 2 separate classes of drugs, our plight is very much the same. Denying people the right to use drugs for their ailments or needs is straight up tyranny IMO.
Is anyone aware of any peripheral acting opioid antagonists that can be found in nature?
I think coffee has peripherally acting opioid antagonists in it, but I'd have to go read up again.
Basically I'm looking for a way that somebody could take buprenorphine & get the CNS effects but have bupes action be blocked in the gut.
I'm guessing because of bupes binding affinity, it's gonna be hard to find anything (especially natural) that can displace it from the receptor in the gut. But I'm curious.
I'd ask a doctor but most know fuck all compared to veteran junkies, pharmacologists & chemists.
Hmmm let's see...
So far
Buprenorphine - PROs : It's more easily accessible & socially acceptable. CONS : Causes longer acting & worse chronic constipation (for me anyway), sedation, lethargy, possible aneurysms, strokes or brain bleeds, etc.. provides almost useless pain relief once tolerance is established, along with very weak antidepressant/mood lift/craving satisfaction compared to full agonists.
