You can't really make blanket statements about which AD is more effective for every patient. Effexor ist for people who need just a tiny bit of extra noradrenaline on top of a large serotonin boost. Cymbalta is for people who need a balanced increase in serotonin and noradrenaline levels. Too much noradrenaline causes a different set of side-effects (some of them sexual), but who knows, it might just hit the sweet spot between serotonin and noradrenaline for you (as I wrote in your other thread, there's also Milnacipran and Reboxetine which are even less serotonergic and more noradrenergic, though I don't think they're as widely available as Cymbalta and Effexor).
thank u, that was informative.
i have been on prozac and lexapro before, both of which i understand are seratonin based.#
they made a minimal impact.
however effexor has alleviated my irritable bowel syndrome, which is fantastic.
I understand some antidepressants have this effect, while some don't.
I believe cymbalta may also have this effect, but I am unsure if drugs like valdoxan or moclobimide carry this property.
Given that effexor is mainly serotonin based, yet the other serotonin drugs made little impact, would suggest that I would benefit more from a drug that acts more profoundly on noradrenaline such as cymbalta.
I will be eager to try a dopamine based drug such as wellbutrin, due to the effect it has on energy, which I require, but that is not licensed here in England and comes only in the form of the smoking cessation agent named zyban.
Would that carry the same property as welbutrin?