I've had horrendous sleep quality for the last few years and I've tried my absolute best to narrow it down. Bloodwork and hormones (from an endo) are perfect, sleep hygiene is perfect and lifestyle factors like stress/depression/anxiety are fine too. I just don't wake up feeling well rested no matter what. I also got tested for sleep apnea but no dice. I have been waiting 2 years now for an in-lab sleep study but I'm tired of waiting.
I'm fairly sure I have some sort of sleeping disorder so I'd like to try gabapentin/baclofen/pregablin but those drugs do have side effects and aren't as good as Xyrem/GHB for pure sleep quality.
I know that there is a lot out there on GHB and sleep but I figured it's a good idea to have a new thread. Xyrem is prescribed at 4.5g twice a night on an empty stomach, is there any risks on using it long-term this way?
My biggest concern is the increase in prolactin - it would have a deleterious effect on dopamine and long-term motivation/energy/drive/libido. The supposed neurotoxicity from NMDA dysregulation shouldn't be too hard to fix with something like agmatine.
I've procured some GHB from the streets last week and have tried it three times so far. I can't attest to its purity but at this point I'm willing to try anything. On Sunday, I was on a fully empty stomach and took 4.5g and slept extremely well! I actually woke up 7 hours later feeling good via the dopamine rebound, not after 3-4 hours that most people get.
On Tuesday I tried 4.5g again but still had food in my stomach from four hours earlier. The result is that I got very pleasantly high and wanted to dance around my room to music and fuck the shit out of a chick. I couldn't sleep at all. I know that food + GHB changes its pharmacodynamics so that its absorbed only 42% and it stretches out its pharmacokinetics.
Last night (Friday), I tried 10.7g on a completely full stomach (I calculated that 4.5g / 0.42 = 10.7g on a full stomach). Same result, couldn't sleep. The high wasn't very pleasant this time and I just felt dizzy/a bit nauseous like a high dose phenibut.
My theory is that you need GHB to act quickly to "knock you out" into that sweet sleep coma but that can only happen on a fully empty stomach to complement its pharmacokinetics.
Anyway, I kind of went on a tangent there. Any info or insight is appreciated as always! I'm thinking for now I can use it 1-3x a week as needed, 4.5g on a fully empty stomach.
I'm fairly sure I have some sort of sleeping disorder so I'd like to try gabapentin/baclofen/pregablin but those drugs do have side effects and aren't as good as Xyrem/GHB for pure sleep quality.
I know that there is a lot out there on GHB and sleep but I figured it's a good idea to have a new thread. Xyrem is prescribed at 4.5g twice a night on an empty stomach, is there any risks on using it long-term this way?
My biggest concern is the increase in prolactin - it would have a deleterious effect on dopamine and long-term motivation/energy/drive/libido. The supposed neurotoxicity from NMDA dysregulation shouldn't be too hard to fix with something like agmatine.
I've procured some GHB from the streets last week and have tried it three times so far. I can't attest to its purity but at this point I'm willing to try anything. On Sunday, I was on a fully empty stomach and took 4.5g and slept extremely well! I actually woke up 7 hours later feeling good via the dopamine rebound, not after 3-4 hours that most people get.
On Tuesday I tried 4.5g again but still had food in my stomach from four hours earlier. The result is that I got very pleasantly high and wanted to dance around my room to music and fuck the shit out of a chick. I couldn't sleep at all. I know that food + GHB changes its pharmacodynamics so that its absorbed only 42% and it stretches out its pharmacokinetics.
Last night (Friday), I tried 10.7g on a completely full stomach (I calculated that 4.5g / 0.42 = 10.7g on a full stomach). Same result, couldn't sleep. The high wasn't very pleasant this time and I just felt dizzy/a bit nauseous like a high dose phenibut.
My theory is that you need GHB to act quickly to "knock you out" into that sweet sleep coma but that can only happen on a fully empty stomach to complement its pharmacokinetics.
Anyway, I kind of went on a tangent there. Any info or insight is appreciated as always! I'm thinking for now I can use it 1-3x a week as needed, 4.5g on a fully empty stomach.