Backfromthebrink
Bluelighter
- Joined
- Sep 22, 2017
- Messages
- 847
^ Back from the Brink, Oxycode has mean BA% around 50%; multiple studies confirm this. And peak plasma levels would be much higher, And oxycodone enters the cns vaster thab morphine
Same reason so Many snort, peaks in 10-15(~) minutes, higher Cmax, generally giBA%(?
If you Google "oral bioavailability of oxycodone" literally every single source puts the oral BA far far higher than 50% with a maximum of 87-90%..
Not sure what multiple studies you are referring to, but every single one I can find doesn't state 50%.
The absolute lowest I coukd find was mean 60% with 20% SD.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006196/
Pharmacokinetic studies of orally administered OxyContin report a mean terminal half-life (t1/2) of approximately 4.5 to 6.5 hours, mean time to maximum concentration (Tmax) of 2.5 to 5 hours, and oral bioavailability equivalent to immediate-release oxycodone (mean 60%, standard deviation [SD] 20%).10-12
Wiki puts it as high as 87%
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